Guadalupe or Guadeloupe may refer to:
France
- Guadeloupe, a French overseas department in the Caribbean
Mexico
- Guadalupe, Baja California
- Guadalupe, Chihuahua
- Guadalupe, Nuevo León, part of the metropolitan area of Monterrey
- Guadalupe Etla, Oaxaca
- Guadalupe, Puebla, see Municipalities of Puebla
- Guadalupe, Zacatecas
- Guadalupe de Ramírez, Oaxaca
- Guadalupe y Calvo, Chihuahua
- Villa de Guadalupe, Mexico City, a town near Mexico City, now a suburb incorporated into the city
- Presa de Guadalupe, lake near Cuautitlán Izcalli
- Guadalupe Island, an oceanic island off Baja California