Santa Cruz (Spanish or Portuguese, 'holy cross') or Santacruz may refer to:
Asia and Oceania
Philippines
- Santa Cruz, Camarines Norte (disambiguation)
- Santa Cruz, Davao del Sur, a municipality in Metropolitan Davao
- Santa Cruz, Ilocos Sur, a municipality in the province of Ilocos Sur
- Santa Cruz, Laguna, a municipality and the capital of Laguna
- Santa Cruz, Manila, a district in the north part of the city
- Santa Cruz, Marinduque, a municipality in the province of Marinduque
- Santa Cruz, Occidental Mindoro, a municipality in the province of Occidental Mindoro
- Santa Cruz, Quezon City, a village in the San Francisco Del Monte district of Quezon City
- Santa Cruz, San Jose, Camarines Sur, a barangay
- Santa Cruz, San Jose, Dinagat Islands, a barangay
- Santa Cruz, Tubajon, Dinagat Islands, a barangay
- Santa Cruz, Zambales, a municipality in the province of Zambales
- Santa Cruz, a barangay in the municipality of Anda, Bohol
- Santa Cruz, a barangay in the municipality of Cagayancillo, Palawan
- Santa Cruz, a barangay in Cebu City
- Santa Cruz, a barangay in Pasig
- Santa Cruz Poblacion, a barangay in Calabanga, Camarines Sur
Europe
Portugal
- Santa Cruz (Almodôvar), civil parish in the municipality of Almodôvar
- Santa Cruz (Coimbra), civil parish in the municipality of Coimbra
- Santa Cruz, Madeira, municipality on the island of Madeira
- Santa Cruz (Praia da Vitória), a civil parish on Terceira Island, Azores
- Santa Cruz (Armamar) [pt], civil parish in Armamar
- Santa Cruz (Santiago do Cacém) [pt], former civil parish in Santiago do Cacém
- Santa Cruz (Torres Vedras), village and beach resort in the parish of Silveira
- Santa Cruz (Vinhais) [pt], civil parish in the municipality of Vinhais
Spain
Municipalities
- Santa Cruz de Bezana, municipality in Cantabria
- Santa Cruz de Boedo, municipality in Palencia
- Santa Cruz de Grío, municipality in Zaragoza
- Santa Cruz de Moncayo, municipality in Zaragoza
- Santa Cruz de Mudela, municipality in Ciudad Real
- Santa Cruz de Nogueras, municipality in Teruel
- Santa Cruz de la Salceda, municipality in Burgos
- Santa Cruz de la Serós, municipality in Huesca
- Santa Cruz de los Cáñamos, municipality in Ciudad Real
- Santa Cruz de La Palma, municipality in the province of Santa Cruz de Tenerife in the Canary Islands
Other places in Spain
- Province of Santa Cruz de Tenerife, containing the islands of Tenerife, La Gomera, El Hierro, and La Palma
- Santa Cruz, an urban area in Oleiros, Galicia
- Santa Cruz (Mieres), a parish in Mieres, Asturias
- Santa Cruz, Seville, city district
- Castillo de Santa Cruz, castle on the Isla de Santa Cruz in A Coruña, Galicia
- Santa Cruz de Tenerife, capital of the Province of Santa Cruz de Tenerife and joint capital of the Canary Islands
- Santa Cruz del Valle de los Caídos, basilica and monument in the Sierra de Guadarrama, near Madrid
North and Central America
- Santa Cruz (canton), Costa Rica, in Guanacaste Province, Costa Rica
- Santa Cruz del Quiché, city in Guatemala
- Santa Cruz, Lempira, a municipality in the department of Lempira, Honduras
- Santa Cruz de Yojoa, municipality in Honduras
- Santa Cruz, Jamaica, town in St. Elizabeth Parish, Jamaica
- Santa Cruz, Trinidad and Tobago, town in the Santa Cruz Valley, Trinidad and Tobago
Mexico
State of Oaxaca
- Santa Cruz Acatepec, town and municipality
- Santa Cruz Amilpas, town and municipality
- Santa Cruz de Bravo, town and municipality
- Santa Cruz Itundujia, town and municipality
- Santa Cruz Mixtepec, town and municipality
- Santa Cruz Nundaco, town and municipality
- Santa Cruz Papalutla, town and municipality
- Santa Cruz Tacache de Mina, town and municipality
- Santa Cruz Tacahua, town and municipality
- Santa Cruz Tayata, town and municipality
- Santa Cruz Xitla, town and municipality
- Santa Cruz Xoxocotlán, town and municipality
- Santa Cruz Zenzontepec, town and municipality
United States
- Santa Cruz, Arizona, a census-designated place (CDP) in Pinal County
- Santa Cruz, Pima County, Arizona, a populated place situated in Pima County
- Santa Cruz County, Arizona
- Santa Cruz River (Arizona), river in southern Arizona and northern Sonora, Mexico
- Santa Cruz County, California
- Santa Cruz, California, county seat and city in Santa Cruz County
- Santa Cruz Island, Santa Barbara County, California
- Santa Cruz (Mariposa County), the former name of Indian Gulch, California
- Santa Cruz, New Mexico
- Santa Cruz, Texas, a former census-designated place in Starr County
- Santa Cruz, Starr County, Texas, a census-designated place in Starr County
- Santa Cruz, the Spanish name for Saint Croix, United States Virgin Islands
South America
Brazil
Municipalities
- Santa Cruz, Paraíba
- Santa Cruz, Rio Grande do Norte
- Santa Cruz do Arari, Pará
- Santa Cruz Cabrália, Bahia
- Santa Cruz da Conceição, São Paulo
- Santa Cruz do Escalvado, Minas Gerais
- Santa Cruz da Esperança, São Paulo
- Santa Cruz de Goiás
- Santa Cruz dos Milagres, Piauí
- Santa Cruz de Minas, Minas Gerais
- Santa Cruz das Palmeiras, São Paulo
- Santa Cruz do Piauí, Piauí
- Santa Cruz do Rio Pardo, São Paulo
- Santa Cruz de Salinas, Minas Gerais
- Santa Cruz da Vitória, Bahia
Peru
- Santa Cruz (mountain), mountain in the Cordillera Blanca
- Santa Cruz District, Alto Amazonas, district of Alto Amazonas Province
- Santa Cruz District, Ancash, district of Huaylas Province
- Santa Cruz de Andamarca District, district of Huaral Province
- Santa Cruz de Chuca District, district of Santiago de Chuco Province
- Santa Cruz de Cocachacra District, district of Huarochirí Province
- Santa Cruz de Flores District, district of Cañete Province
- Santa Cruz District, Palpa, district of Palpa Province
- Santa Cruz District, Santa Cruz, district and capital of Santa Cruz Province
- Santa Cruz de Toledo District, district of Contumazá Province
- Santa Cruz, Satipo, Peru, a settlement founded by Franciscans in 1673
- Santa Cruz Province, Peru, province in the Cajamarca Region
- Santa Cruz Beach Boardwalk, oceanfront amusement park, Santa Cruz, California
- Santa Cruz Bicycles, American bicycle manufacturer
- Santa Cruz Games, video game company
- Santa Cruz Guitar Company, American manufacturer of acoustic guitars, Santa Cruz, California
- Santa Cruz Operation, software company
- Santa Cruz Skateboards, American brand of skateboards manufactured by NHS, Inc.
- Santa Cruz, sound card manufactured by Turtle Beach Systems
Brazil
- Associação Atlética Santa Cruz, football club in Salinópolis
- Futebol Clube Santa Cruz, football club in Santa Cruz do Sol
- Santa Cruz Esporte Clube, football club in Barra do Bugres
- Santa Cruz Futebol Clube, football club in Recife
- Santa Cruz Futebol Clube (MG), football club in Belo Horizonte
- Santa Cruz Futebol Clube (RJ), football club in Rio de Janeiro
- Santa Cruz Futebol Clube (RN), football club in Natal
- Santa Cruz Recreativo Esporte Clube, football club in Santa Rita
- Sport Club Santa Cruz, football club in Santa Cruz, Rio Grande do Norte