Glemanserin

Glemanserin (INN; developmental code MDL-11,939) is a drug which acts as a potent and selective 5-HT_2A receptor antagonist.^[1] The first truly selective 5-HT_2A ligand to be discovered, glemanserin resulted in the development of the widely used and even more potent and selective 5-HT_2A receptor antagonist volinanserin (MDL-100,907), which is a fluorinated analogue.^[2] Though it was largely superseded in scientific research by volinanserin, glemanserin was investigated clinically for the treatment of generalized anxiety disorder.^[3] However, it was ultimately found to be ineffective and was not marketed.^[3]

Glemanserin

Clinical data
ATC code	None
Identifiers
IUPAC name α-phenyl-1-(2-phenylethyl)-4-piperidine methanol
CAS Number	132553-86-7
PubChem CID	71781
ChemSpider	64815
UNII	X96LS7MC5Z
CompTox Dashboard (EPA)	DTXSID4042624
Chemical and physical data
Formula	C20H25NO
Molar mass	295.426 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC(c1ccccc1)C3CCN(CCc2ccccc2)CC3
InChI InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2 Key:AXNGJCOYCMDPQG-UHFFFAOYSA-N

See also

• Volinanserin
• Pruvanserin
• Roluperidone
• Lenperone
• Lidanserin