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Gidazepam

Benzodiazepine medication From Wikipedia, the free encyclopedia

Gidazepam
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Gidazepam, also known as hydazepam or hidazepam,[2] is a drug which is an atypical benzodiazepine derivative, developed in the Soviet Union.[3][4] It is a selectively anxiolytic benzodiazepine.[5] It also has therapeutic value in the management of certain cardiovascular disorders.[6][7][8][9][10]

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Pharmacology

Gidazepam and several of its analogs, in contrast to other benzodiazepines, are comparatively more selective agonists of TSPO (formerly the peripheral benzodiazepine receptor) than the benzodiazepine receptor.[5]

Gidazepam acts as a prodrug to its active metabolite 7-bromo-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (desalkylgidazepam or bromo-nordazepam).[11][12] Its anxiolytic effects can take several hours to manifest presumably due to its slow metabolism (half-life 87 hours). The onset and intensity of anxiolytic effects correlate with blood levels of desalkylgidazepam.[13]

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Gidazepam active metabolite (desalkylgidazepam), responsible for its therapeutic effects
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See also

References

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