GX P2V

GX_P2V is a COVID-19 mutant strain that is fatal to humanized mice with the hACE2 gene. ^[1] The Chinese government has been performing tests on GX_P2V and has published a new study.^[2] “This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2 related viruses," the paper's authors wrote. ^[3] GX_P2V infected the lungs, bones, eyes, tracheas and brains of the four lab mice tested.^[4]

All four lab mice died rapidly after eight days due to severe vision impairment; particularly white eyes, severe weight loss, and poor movement. ^[5][6]

References

1. Liu, Kuo; Tang, Muxue; Xu, Wei; Meng, Xinfeng; Jin, Hengwei; Han, Maoying; Pu, Jing; Li, Yutang; Jiao, Fanke; Sun, Ruilin; Shen, Ruling; Lui, Kathy O.; Lu, Lu; Zhou, Bin (2023). "An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo". Proceedings of the National Academy of Sciences. 120 (25): e2207210120. Bibcode:2023PNAS..12007210L. doi:10.1073/pnas.2207210120. PMC 10288645. PMID 37307455.
2. Wei, Lai; Liu, Shuiqing; Lu, Shanshan; Luo, Shengdong; An, Xiaoping; Fan, Huahao; Chen, Weiwei; Li, Erguang; Tong, Yigang (2024-01-04). An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) (Report). Microbiology. doi:10.1101/2024.01.03.574008.
3. "Chinese lab crafts mutant COVID-19 strain with 100% kill rate in 'humanized' mice: 'Surprisingly' rapid death". N.Y. Post. 17 January 2024.
4. "Chinese scientists create mutant COVID strain that kills mice". Toronto Sun. 2024-01-17. Retrieved 2024-01-22.
5. White, Caleb (2024-01-17). "What Is GX_P2V? Mutant Coronavirus Strain Kills Humanized Mice Within 8 Days [Study]". The Science Times. Retrieved 2024-01-22.
6. Donlevy, Katherine (2024-01-17). "Chinese lab crafts mutant COVID strain with 100% kill rate in 'humanized' mice: 'Surprisingly' rapid death". New York Post. Retrieved 2024-05-15.