GMCL1

Germ cell-less, spermatogenesis associated 1 is a protein that in humans is encoded by the GMCL1 gene. ^[5]

GMCL1
Identifiers
Aliases	GMCL1, BTBD13, GCL, GCL1, SPATA29, germ cell-less, spermatogenesis associated 1, germ cell-less 1, spermatogenesis associated
External IDs	MGI: 1345156; HomoloGene: 8021; GeneCards: GMCL1; OMA:GMCL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 69,829,660 bp[1] End 69,881,384 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 37.75 cM Start 86,668,750 bp[2] End 86,710,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad testicle Achilles tendon rectum monocyte islet of Langerhans duodenum Epithelium of choroid plexus jejunal mucosa Top expressed in spermatocyte superior cervical ganglion seminiferous tubule cumulus cell molar trigeminal ganglion medullary collecting duct hair follicle primary oocyte secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding Cellular component nuclear matrix nuclear envelope ubiquitin ligase complex nucleus Biological process multicellular organism development cell differentiation regulation of transcription, DNA-templated spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64395 23885 Ensembl ENSG00000087338 ENSMUSG00000001157 UniProt Q96IK5 Q920G9 RefSeq (mRNA) NM_178439 NM_011818 RefSeq (protein) NP_848526 NP_035948 Location (UCSC) Chr 2: 69.83 – 69.88 Mb Chr 6: 86.67 – 86.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly related protein.

References

1. GRCh38: Ensembl release 89: ENSG00000087338 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001157 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Germ cell-less, spermatogenesis associated 1". Retrieved 2015-09-17.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.