GDF7

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.^[5]

GDF7
Identifiers
Aliases	GDF7, BMP12, growth differentiation factor 7
External IDs	OMIM: 604651; MGI: 95690; HomoloGene: 32177; GeneCards: GDF7; OMA:GDF7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.1 Start 20,667,144 bp[1] End 20,679,243 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 8,347,918 bp[2] End 8,351,954 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula endometrium Descending thoracic aorta ascending aorta mucosa of paranasal sinus ectocervix right coronary artery canal of the cervix kidney tubule popliteal artery Top expressed in uterus embryo finger foot shoulder toe rhombencephalon cerebellar cortex striatum of neuraxis primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity protein homodimerization activity protein binding transforming growth factor beta receptor binding growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process pathway-restricted SMAD protein phosphorylation cell fate commitment epithelial cell differentiation regulation of MAPK cascade SMAD protein signal transduction spinal cord association neuron differentiation cell development positive regulation of tendon cell differentiation positive regulation of pathway-restricted SMAD protein phosphorylation roof plate formation BMP signaling pathway axon guidance reproductive structure development positive regulation of transcription, DNA-templated forebrain morphogenesis gland morphogenesis positive regulation of gene expression positive regulation of neuron differentiation neural tube development branching morphogenesis of an epithelial tube midbrain development activin receptor signaling pathway morphogenesis of an epithelial fold regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151449 238057 Ensembl ENSG00000143869 ENSMUSG00000037660 UniProt Q7Z4P5 P43029 RefSeq (mRNA) NM_182828 NM_013527 NM_001312876 RefSeq (protein) NP_878248 NP_001299805 NP_038555 Location (UCSC) Chr 2: 20.67 – 20.68 Mb Chr 12: 8.35 – 8.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.^[5][6]

GDF7 is also known as bone morphogenic protein 12 (BMP-12).^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143869 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037660 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
6. Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA. 102 (20): 7192–7. Bibcode:2005PNAS..102.7192L. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.
7. Peng C, Lei C, Guofei C, Tian Y, Wei L, Jianwei Z, Chen W, Wentao Z, Changqing J (2019). "The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair". International Journal of Biological Macromolecules. 138: 79–88. doi:10.1016/j.ijbiomac.2019.07.041. PMID 31295489. S2CID 195892657.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Davidson AJ, Postlethwait JH, Yan YL, et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976.
• Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons". Neuron. 38 (3): 389–401. doi:10.1016/S0896-6273(03)00254-X. PMID 12741987. S2CID 6434429.
• Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014. S2CID 23693180.