GATAD2B

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.^[5][6][7]

GATAD2B
Identifiers
Aliases	GATAD2B, MRD18, P66beta, p68, GATA zinc finger domain containing 2B, GANDS
External IDs	OMIM: 614998; MGI: 2443225; HomoloGene: 32484; GeneCards: GATAD2B; OMA:GATAD2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,789,030 bp[1] End 153,923,360 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,200,485 bp[2] End 90,270,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon corpus callosum bone marrow cells skeletal muscle tissue blood tonsil ganglionic eminence sural nerve ventricular zone cerebellum Top expressed in secondary oocyte zygote ascending aorta aortic valve Rostral migratory stream primary oocyte supraoptic nucleus genital tubercle tail of embryo cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleosomal DNA binding sequence-specific DNA binding zinc ion binding protein binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear speck nucleus nucleoplasm NuRD complex protein-containing complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57459 229542 Ensembl ENSG00000143614 ENSG00000261992 ENSMUSG00000042390 UniProt Q8WXI9 Q8VHR5 RefSeq (mRNA) NM_020699 NM_139304 NM_001379655 NM_001379656 NM_001379657 RefSeq (protein) NP_065750 NP_647465 NP_001366584 NP_001366585 NP_001366586 Location (UCSC) Chr 1: 153.79 – 153.92 Mb Chr 3: 90.2 – 90.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2,^[6][8] MBD3,^[6][8] RBBP7^[6] and RBBP4.^[6]

References

1. ENSG00000261992 GRCh38: Ensembl release 89: ENSG00000143614, ENSG00000261992 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042390 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461. S2CID 263221761.
6. Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (Dec 2001). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol Cell Biol. 22 (2): 536–46. doi:10.1128/MCB.22.2.536-546.2002. PMC 139742. PMID 11756549.
7. "Entrez Gene: GATAD2B GATA zinc finger domain containing 2B".
8. Brackertz M, Boeke Joern, Zhang Ru, Renkawitz Rainer (Oct 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43). United States: 40958–66. doi:10.1074/jbc.M207467200. ISSN 0021-9258. PMID 12183469.

Further reading

• Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Brackertz M, Gong Z, Leers J, Renkawitz R (2006). "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction". Nucleic Acids Res. 34 (2): 397–406. doi:10.1093/nar/gkj437. PMC 1331983. PMID 16415179.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.