GAS7

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.^[5][6]

GAS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LX7, 2YSH
Identifiers
Aliases	GAS7, MLL/growth arrest specific 7
External IDs	OMIM: 603127; MGI: 1202388; HomoloGene: 69015; GeneCards: GAS7; OMA:GAS7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 9,910,606 bp[1] End 10,198,606 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 67,345,917 bp[2] End 67,575,800 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis Parietal Lobe Brodmann area 10 postcentral gyrus trigeminal ganglion external globus pallidus sural nerve olfactory bulb inferior ganglion of vagus nerve spinal ganglia Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus neural layer of retina cerebellar cortex gastrula lobe of cerebellum primary visual cortex cerebellar vermis nucleus accumbens esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein binding cytoskeletal protein binding actin filament binding Cellular component cytoplasm cytoskeleton actin filament plasma membrane Biological process multicellular organism development cell differentiation nervous system development regulation of transcription, DNA-templated actin filament polymerization neuron differentiation neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8522 14457 Ensembl ENSG00000007237 ENSMUSG00000033066 UniProt O60861 Q60780 RefSeq (mRNA) NM_001130831 NM_003644 NM_201432 NM_201433 NM_001109657 NM_001277079 NM_001277080 NM_008088 RefSeq (protein) NP_001124303 NP_003635 NP_958836 NP_958839 n/a Location (UCSC) Chr 17: 9.91 – 10.2 Mb Chr 11: 67.35 – 67.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.^[6]