GAS7

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.^[5][6]

GAS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LX7, 2YSH
Identifiers
Aliases	GAS7, MLL/growth arrest specific 7
External IDs	OMIM: 603127; MGI: 1202388; HomoloGene: 69015; GeneCards: GAS7; OMA:GAS7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 9,910,606 bp[1] End 10,198,606 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 67,345,917 bp[2] End 67,575,800 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis Parietal Lobe Brodmann area 10 postcentral gyrus trigeminal ganglion external globus pallidus sural nerve olfactory bulb inferior ganglion of vagus nerve spinal ganglia Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus neural layer of retina cerebellar cortex gastrula lobe of cerebellum primary visual cortex cerebellar vermis nucleus accumbens esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein binding cytoskeletal protein binding actin filament binding Cellular component cytoplasm cytoskeleton actin filament plasma membrane Biological process multicellular organism development cell differentiation nervous system development regulation of transcription, DNA-templated actin filament polymerization neuron differentiation neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8522 14457 Ensembl ENSG00000007237 ENSMUSG00000033066 UniProt O60861 Q60780 RefSeq (mRNA) NM_001130831 NM_003644 NM_201432 NM_201433 NM_001109657 NM_001277079 NM_001277080 NM_008088 RefSeq (protein) NP_001124303 NP_003635 NP_958836 NP_958839 n/a Location (UCSC) Chr 17: 9.91 – 10.2 Mb Chr 11: 67.35 – 67.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000007237 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033066 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S (Oct 1998). "gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation". Proc Natl Acad Sci U S A. 95 (19): 11423–11428. Bibcode:1998PNAS...9511423J. doi:10.1073/pnas.95.19.11423. PMC 21658. PMID 9736752.
6. "Entrez Gene: GAS7 growth arrest-specific 7".

Further reading

• Kurtz A, Zimmer A (1995). "Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17". Mamm. Genome. 6 (5): 379–380. doi:10.1007/BF00364810. PMID 7626897. S2CID 32467578.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Megonigal MD, Cheung NK, Rappaport EF, et al. (2000). "Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2814–2819. Bibcode:2000PNAS...97.2814M. doi:10.1073/pnas.050397097. PMC 16012. PMID 10706619.
• She BR, Liou GG, Lin-Chao S (2002). "Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth". Exp. Cell Res. 273 (1): 34–44. doi:10.1006/excr.2001.5435. PMID 11795944.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chao CC, Chang PY, Lu HH (2005). "Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth". J. Neurosci. Res. 81 (2): 153–162. doi:10.1002/jnr.20552. PMID 15948147. S2CID 9789678.