Fluocinonide

Fluocinonide
Clinical data
Trade names	Fluonex, Lidex, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601054
Routes of; administration	Topical
ATC code	C05AA11 (WHO) D07AC08 (WHO), QC05AA11 (WHO), QD07AC08 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Metabolism	Liver
Identifiers
	IUPAC name 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate;
CAS Number	356-12-7 ;
PubChem CID	9642;
IUPHAR/BPS	7078;
DrugBank	DB01047 ;
ChemSpider	9265 ;
UNII	2W4A77YPAN;
KEGG	D00325 ;
ChEMBL	ChEMBL1501 ;
CompTox Dashboard (EPA)	DTXSID8045307 ;
ECHA InfoCard	100.005.998
Chemical and physical data
Formula	C26H32F2O7
Molar mass	494.532 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C;
	InChI InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 ; Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N ;
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Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis.^[2] It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.^[2]

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A common potential adverse effect is skin atrophy (thinning of the skin).^[3]

In 2022, it was the 266th most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[4]^[5]

Veterinary uses