FSCN3

Fascin-3 also known as testis fascin is a protein that in humans is encoded by the FSCN3 gene.^[5][6]

FSCN3
Identifiers
Aliases	FSCN3, fascin actin-bundling protein 3
External IDs	OMIM: 615800; MGI: 1890386; HomoloGene: 10475; GeneCards: FSCN3; OMA:FSCN3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 127,591,409 bp[1] End 127,602,144 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 28,427,788 bp[2] End 28,438,621 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis testicle granulocyte gonad muscle of thigh cerebellar cortex cerebellar hemisphere prefrontal cortex Top expressed in seminiferous tubule spermatid blastocyst embryo spermatocyte embryo upper arm medial ganglionic eminence triceps brachii muscle yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function protein-macromolecule adaptor activity actin binding actin filament binding Cellular component cytoskeleton actin cytoskeleton cytoplasm filamentous actin ruffle microvillus lamellipodium filopodium growth cone cell projection membrane Biological process spermatid development actin filament organization anatomical structure morphogenesis establishment or maintenance of cell polarity actin filament bundle assembly cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29999 56223 Ensembl ENSG00000106328 ENSMUSG00000029707 UniProt Q9NQT6 Q9QXW4 RefSeq (mRNA) NM_020369 NM_019569 RefSeq (protein) NP_065102 NP_062515 Location (UCSC) Chr 7: 127.59 – 127.6 Mb Chr 6: 28.43 – 28.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Fascin

References

1. GRCh38: Ensembl release 89: ENSG00000106328 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029707 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: fascin homolog 3".
6. Tubb B, Mulholland DJ, Vogl W, Lan ZJ, Niederberger C, Cooney A, Bryan J (April 2002). "Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head". Exp. Cell Res. 275 (1): 92–109. doi:10.1006/excr.2002.5486. PMID 11925108.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Tubb BE, Bardien-Kruger S, Kashork CD, et al. (2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.