FRAT1

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.^[5][6]

FRAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ
Identifiers
Aliases	FRAT1, WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
External IDs	OMIM: 602503; MGI: 109450; HomoloGene: 3999; GeneCards: FRAT1; OMA:FRAT1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 97,319,271 bp[1] End 97,321,915 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 35.3 cM Start 41,818,409 bp[2] End 41,821,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte testicle granulocyte pancreatic ductal cell secondary oocyte gonad right lobe of liver bone marrow spleen Top expressed in spermatid granulocyte muscle of thigh neural layer of retina embryo spermatocyte morula duodenum CA3 field Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol intracellular membrane-bounded organelle cytoplasm Biological process Wnt signaling pathway beta-catenin destruction complex disassembly canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10023 14296 Ensembl ENSG00000165879 ENSMUSG00000067199 UniProt Q92837 P70339 RefSeq (mRNA) NM_181355 NM_005479 NM_008043 RefSeq (protein) NP_005470 NP_032069 Location (UCSC) Chr 10: 97.32 – 97.32 Mb Chr 19: 41.82 – 41.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000165879 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067199 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC 1169648. PMID 9034327.
6. "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".

Further reading

• Li L, Yuan H, Weaver CD, et al. (1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1". EMBO J. 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. PMC 1171499. PMID 10428961.
• Saitoh T, Katoh M (2001). "FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". Int. J. Oncol. 19 (2): 311–5. doi:10.3892/ijo.19.2.311. PMID 11445844.
• Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation". Structure. 9 (12): 1143–52. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
• Saitoh T, Mine T, Katoh M (2002). "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer". Int. J. Oncol. 20 (4): 785–9. doi:10.3892/ijo.20.4.785. PMID 11894125.
• Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene. 291 (1–2): 17–27. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hino S, Michiue T, Asashima M, Kikuchi A (2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin". J. Biol. Chem. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519.
• Khambata-Ford S, Liu Y, Gleason C, et al. (2003). "Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay". Genome Res. 13 (7): 1765–74. doi:10.1101/gr.529803. PMC 403750. PMID 12805274.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang Y, Hewitt SM, Liu S, et al. (2006). "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours". Br. J. Cancer. 94 (5): 686–91. doi:10.1038/sj.bjc.6602988. PMC 2361213. PMID 16479254.
• Hagen T, Cross DA, Culbert AA, et al. (2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J. Biol. Chem. 281 (46): 35021–9. doi:10.1074/jbc.M607003200. PMID 16982607.

External links

• FRAT1 human gene location in the UCSC Genome Browser.
• FRAT1 human gene details in the UCSC Genome Browser.