FOXH1

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.^[5][6]

FOXH1
Identifiers
Aliases	FOXH1, FAST-1, FAST1, forkhead box H1
External IDs	OMIM: 603621; MGI: 1347465; HomoloGene: 2914; GeneCards: FOXH1; OMA:FOXH1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,473,412 bp[1] End 144,475,849 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,552,425 bp[2] End 76,554,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad mucosa of transverse colon islet of Langerhans middle temporal gyrus rectum mucosa of nose duodenum nucleus accumbens occipital lobe Top expressed in epiblast embryo lumbar spinal ganglion embryo blastocyst primitive endoderm primitive streak spermatid morula spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-SMAD binding transcription coregulator activity protein domain specific binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific androgen receptor binding DNA-binding transcription factor activity bHLH transcription factor binding DNA binding protein binding R-SMAD binding SMAD binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm activin responsive factor complex transcription regulator complex nucleus Biological process ventricular trabecula myocardium morphogenesis anterior/posterior pattern specification negative regulation of androgen receptor signaling pathway embryonic heart tube anterior/posterior pattern specification transcription, DNA-templated outflow tract morphogenesis nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry regulation of transcription by RNA polymerase II heart looping axial mesoderm development cardiac right ventricle morphogenesis negative regulation of transcription by RNA polymerase II determination of left/right symmetry secondary heart field specification positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated aorta morphogenesis transcription by RNA polymerase II negative regulation of intracellular estrogen receptor signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of transcription by RNA polymerase II cellular response to cytokine stimulus anatomical structure morphogenesis cell differentiation negative regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8928 14106 Ensembl ENSG00000160973 ENSMUSG00000033837 UniProt O75593 O88621 RefSeq (mRNA) NM_003923 NM_007989 RefSeq (protein) NP_003914 NP_032015 Location (UCSC) Chr 8: 144.47 – 144.48 Mb Chr 15: 76.55 – 76.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.^[6]

FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking FoxH1 will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.

Interactions

FOXH1 has been shown to interact with DRAP1^[7] and Mothers against decapentaplegic homolog 2.^{[8][9][10][11][12]}

See also

• FOX proteins

References

1. ·     Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072
2. Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001;15(10):1257-1271. doi:10.1101/gad.881501
3. ·     von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023

1. GRCh38: Ensembl release 89: ENSG00000160973 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033837 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (July 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Molecular Cell. 2 (1): 121–127. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.
6. "Entrez Gene: FOXH1 forkhead box H1".
7. Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, et al. (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–1999. Bibcode:2002Sci...298.1996I. doi:10.1126/science.1073405. PMID 12471260. S2CID 22923124.
8. Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400. S2CID 6907878.
9. Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Molecular and Cellular Biology. 19 (1): 424–430. doi:10.1128/MCB.19.1.424. PMC 83900. PMID 9858566.
10. Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes & Development. 11 (23): 3157–3167. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
11. Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Molecular and Cellular Biology. 20 (17): 6201–6211. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
12. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–89. Bibcode:1997Natur.389...85C. doi:10.1038/38008. PMID 9288972. S2CID 11927346.

Further reading

• Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–89. Bibcode:1997Natur.389...85C. doi:10.1038/38008. PMID 9288972. S2CID 11927346.
• Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes & Development. 11 (23): 3157–3167. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
• Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Molecular and Cellular Biology. 19 (1): 424–430. doi:10.1128/MCB.19.1.424. PMC 83900. PMID 9858566.
• Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Molecular and Cellular Biology. 20 (17): 6201–6211. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, et al. (May 2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6198–6203. Bibcode:2001PNAS...98.6198P. doi:10.1073/pnas.101579798. PMC 33445. PMID 11371641.
• Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, et al. (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–1999. Bibcode:2002Sci...298.1996I. doi:10.1126/science.1073405. PMID 12471260. S2CID 22923124.
• Seoane J, Le HV, Shen L, Anderson SA, Massagué J (April 2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell. 117 (2): 211–223. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259. S2CID 15602655.
• von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, et al. (September 2004). "Foxh1 is essential for development of the anterior heart field". Developmental Cell. 7 (3): 331–345. doi:10.1016/j.devcel.2004.07.023. PMID 15363409.
• Kelemen SF, Eisen HJ, Autieri MV (March 2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells". The Journal of Heart and Lung Transplantation. 24 (3): 246–250. doi:10.1016/j.healun.2004.01.015. PMID 15737749.
• Cui Q, Lim SK, Zhao B, Hoffmann FM (June 2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene. 24 (24): 3864–3874. doi:10.1038/sj.onc.1208556. PMID 15750622.
• Hart AH, Willson TA, Wong M, Parker K, Robb L (August 2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochemical and Biophysical Research Communications. 333 (4): 1361–1369. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.
• Chen G, Nomura M, Morinaga H, Matsubara E, Okabe T, Goto K, et al. (October 2005). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor". The Journal of Biological Chemistry. 280 (43): 36355–36363. doi:10.1074/jbc.M506147200. PMID 16120611.

External links

• FOXH1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.