FOXF2

Forkhead box protein F2 is a protein that in humans is encoded by the FOXF2 gene.^[5][6]

FOXF2
Identifiers
Aliases	FOXF2, FKHL6, FREAC-2, FREAC2, forkhead box F2
External IDs	OMIM: 603250; MGI: 1347479; HomoloGene: 1115; GeneCards: FOXF2; OMA:FOXF2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.3 Start 1,389,576 bp[1] End 1,395,603 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 31,809,799 bp[2] End 31,815,386 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber urethra gastric mucosa lower lobe of lung pylorus muscle layer of sigmoid colon gonad right lung mucosa of ileum transverse colon Top expressed in molar left lung lobe sclerotome tongue mandibular prominence finger urethra genital tubercle Hindgut migratory enteric neural crest cell More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity DNA binding transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific protein binding Cellular component transcription regulator complex nucleus Biological process transcription, DNA-templated genitalia development positive regulation of transcription, DNA-templated roof of mouth development regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II epithelial to mesenchymal transition transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation extracellular matrix organization establishment of planar polarity of embryonic epithelium negative regulation of transcription, DNA-templated embryonic digestive tract development embryonic camera-type eye morphogenesis protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2295 14238 Ensembl ENSG00000137273 ENSMUSG00000038402 UniProt Q12947 O54743 RefSeq (mRNA) NM_001452 NM_010225 RefSeq (protein) NP_001443 NP_034355 Location (UCSC) Chr 6: 1.39 – 1.4 Mb Chr 13: 31.81 – 31.82 Mb PubMed search [3] [4]
Wikidata
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Location

The FOXF2 gene is on the short arm of chromosome 6 at position 24.^[5]

Function

The FOXF2 gene belongs to the forkhead family, also known as FOX proteins, which is a family of transcription factors characterized by a distinct forkhead domain. FOXF2 helps regulate several pulmonary genes, and is expressed in the lungs and placenta.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000137273 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038402 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FOXF2 forkhead box F2".
6. Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.