FLT4

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.^[5][6]

FLT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BSJ, 4BSK
Identifiers
Aliases	FLT4, FLT41, LMPH1A, PCL, VEGFR3, FLT-4, VEGFR-3, fms related tyrosine kinase 4, LMPHM1, fms related receptor tyrosine kinase 4, CHTD7
External IDs	OMIM: 136352; MGI: 95561; HomoloGene: 7321; GeneCards: FLT4; OMA:FLT4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 180,601,506 bp[1] End 180,649,624 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.2|11 29.69 cM Start 49,500,090 bp[2] End 49,543,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland apex of heart right lung upper lobe of left lung sural nerve spleen right uterine tube left uterine tube body of uterus Top expressed in endothelial cell of lymphatic vessel internal carotid artery left lobe of liver decidua external carotid artery mesenteric lymph nodes left lung left lung lobe right lung aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity transferase activity nucleotide binding protein kinase activity growth factor binding kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity protein phosphatase binding ATP binding protein homodimerization activity receptor tyrosine kinase transmembrane signaling receptor activity vascular endothelial growth factor binding Cellular component cytoplasm integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane extracellular region nucleus nucleoplasm Biological process regulation of blood vessel remodeling positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation blood vessel morphogenesis lymphangiogenesis phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein kinase C signaling negative regulation of apoptotic process sprouting angiogenesis positive regulation of JNK cascade lymph vessel development positive regulation of endothelial cell migration protein phosphorylation vascular endothelial growth factor receptor signaling pathway vasculature development angiogenesis positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade protein autophosphorylation positive regulation of vascular endothelial growth factor production peptidyl-tyrosine phosphorylation cellular response to vascular endothelial growth factor stimulus positive regulation of MAPK cascade lung alveolus development respiratory system process respiratory gaseous exchange by respiratory system vascular endothelial growth factor signaling pathway negative regulation of signal transduction cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2324 14257 Ensembl ENSG00000037280 ENSMUSG00000020357 UniProt P35916 P35917 RefSeq (mRNA) NM_002020 NM_182925 NM_001354989 NM_008029 RefSeq (protein) NP_002011 NP_891555 NP_001341918 NP_032055 Location (UCSC) Chr 5: 180.6 – 180.65 Mb Chr 11: 49.5 – 49.54 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.^[5]

Interactions

FLT4 has been shown to interact with SHC1.^[7][8][9]

See also

• VEGF receptors