FLRT3

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.^[5][6]

FLRT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CMN, 5CMP
Identifiers
Aliases	FLRT3, HH21, fibronectin leucine rich transmembrane protein 3
External IDs	OMIM: 604808; MGI: 1918686; HomoloGene: 8322; GeneCards: FLRT3; OMA:FLRT3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.1 Start 14,322,985 bp[1] End 14,337,614 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F3 Start 140,492,834 bp[2] End 140,513,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell lower lobe of lung pericardium Brodmann area 23 middle temporal gyrus renal medulla visceral pleura germinal epithelium jejunal mucosa hair follicle Top expressed in genital tubercle hand abdominal wall tail of embryo hair follicle mandibular prominence otolith organ ganglionic eminence maxillary prominence olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein homodimerization activity fibroblast growth factor receptor binding protein kinase inhibitor activity protein binding chemorepellent activity Cellular component cytoplasm axon terminus integral component of membrane synaptic membrane cell projection endoplasmic reticulum membrane membrane cell-cell junction focal adhesion axonal growth cone integral component of plasma membrane extracellular region axon endoplasmic reticulum extracellular space cytosol plasma membrane cell junction extracellular matrix glutamatergic synapse integral component of postsynaptic membrane Biological process negative chemotaxis negative regulation of protein kinase activity cytokine-mediated signaling pathway head development neuron projection extension axon guidance multicellular organism development heart development cell adhesion response to axon injury embryonic morphogenesis proepicardium cell migration involved in pericardium morphogenesis synapse assembly neuron projection development negative regulation of receptor signaling pathway via JAK-STAT positive regulation of synapse assembly fibroblast growth factor receptor signaling pathway cell-cell adhesion via plasma-membrane adhesion molecules synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23767 71436 Ensembl ENSG00000125848 ENSMUSG00000051379 UniProt Q9NZU0 Q8BGT1 RefSeq (mRNA) NM_013281 NM_198391 NM_001172160 NM_178382 RefSeq (protein) NP_037413 NP_938205 NP_001165631 NP_848469 Location (UCSC) Chr 20: 14.32 – 14.34 Mb Chr 2: 140.49 – 140.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125848 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051379 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lacy SE, Bonnemann CG, Buzney EA, Kunkel LM (Mar 2000). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
6. "Entrez Gene: FLRT3 fibronectin leucine rich transmembrane protein 3".

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.