FCGR3A

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.^[5][6] It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

FCGR3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AY4, 3SGJ, 3SGK, 3WN5, 5D6D, 5BW7
Identifiers
Aliases	FCGR3A, CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, Fc fragment of IgG receptor IIIa, Fc gamma receptor IIIa, FcGRIIIA, CD16-II
External IDs	OMIM: 146740; MGI: 2179523; HomoloGene: 477; GeneCards: FCGR3A; OMA:FCGR3A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,541,759 bp[1] End 161,550,737 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 78.53 cM Start 170,846,489 bp[2] End 170,857,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen appendix placenta right lung upper lobe of left lung C1 segment left adrenal gland Top expressed in granulocyte ileum jejunum spleen liver ovary secondary oocyte bone marrow adrenal gland embryo More reference expression data BioGPS n/a
Gene ontology Molecular function IgG binding Cellular component integral component of membrane extracellular region plasma membrane extracellular exosome external side of plasma membrane membrane Biological process immune response Fc-gamma receptor signaling pathway involved in phagocytosis regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2214 246256 Ensembl ENSG00000203747 ENSMUSG00000059089 UniProt P08637 A0A0B4J1G0 RefSeq (mRNA) NM_000569 NM_001127592 NM_001127593 NM_001127595 NM_001127596 NM_001329120 NM_001329122 NM_001386450 NM_144559 NM_180961 RefSeq (protein) NP_000560 NP_001121064 NP_001121065 NP_001121067 NP_001121068 NP_001316049 NP_001316051 NP_653142 Location (UCSC) Chr 1: 161.54 – 161.55 Mb Chr 1: 170.85 – 170.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000203747 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059089 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (May 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
6. "Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)".

Further reading

• Anderson P, Caligiuri M, O'Brien C, Manley T, Ritz J, Schlossman SF (March 1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells". Proceedings of the National Academy of Sciences of the United States of America. 87 (6): 2274–8. Bibcode:1990PNAS...87.2274A. doi:10.1073/pnas.87.6.2274. PMC 53669. PMID 2138330.
• Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23". Immunogenetics. 32 (3): 183–6. doi:10.1007/BF02114971. PMID 2146219. S2CID 23874749.
• Ory PA, Clark MR, Kwoh EE, Clarkson SB, Goldstein IM (November 1989). "Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils". The Journal of Clinical Investigation. 84 (5): 1688–91. doi:10.1172/JCI114350. PMC 304039. PMID 2478590.
• Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW (February 1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 1013–7. Bibcode:1989PNAS...86.1013P. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732.
• Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP (July 1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proceedings of the National Academy of Sciences of the United States of America. 86 (13): 5079–83. Bibcode:1989PNAS...86.5079S. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780.
• Ravetch JV, Perussia B (August 1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". The Journal of Experimental Medicine. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846.
• Simmons D, Seed B (June 1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature. 333 (6173): 568–70. Bibcode:1988Natur.333..568S. doi:10.1038/333568a0. PMID 2967436. S2CID 4351255.
• Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (July 1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599–606. PMID 7516890.
• Detmers PA, Zhou D, Powell D, Lichenstein H, Kelley M, Pironkova R (August 1995). "Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase". Journal of Immunology. 155 (4): 2085–95. doi:10.4049/jimmunol.155.4.2085. PMID 7543538.
• Morcos M, Hänsch GM, Schönermark M, Ellwanger S, Härle M, Heckl-Ostreicher B (December 1994). "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor". Kidney International. 46 (6): 1627–34. doi:10.1038/ki.1994.462. PMID 7700021.
• Schumann G, Dasgupta JD (September 1994). "Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif". International Immunology. 6 (9): 1383–92. doi:10.1093/intimm/6.9.1383. PMID 7819147.
• Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (January 1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". The Journal of Biological Chemistry. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Altin JG, Pagler EB, Kinnear BF, Warren HS (February 1994). "Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells". Immunology and Cell Biology. 72 (1): 87–96. doi:10.1038/icb.1994.13. PMID 8157290. S2CID 23222586.
• Pignata C, Prasad KV, Robertson MJ, Levine H, Rudd CE, Ritz J (December 1993). "Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells". Journal of Immunology. 151 (12): 6794–800. doi:10.4049/jimmunol.151.12.6794. PMID 8258691.
• Cone JC, Lu Y, Trevillyan JM, Bjorndahl JM, Phillips CA (October 1993). "Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells". European Journal of Immunology. 23 (10): 2488–97. doi:10.1002/eji.1830231017. PMID 8405050. S2CID 3112369.
• de Haas M, Koene HR, Kleijer M, de Vries E, Simsek S, van Tol MJ, Roos D, von dem Borne AE (April 1996). "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa". Journal of Immunology. 156 (8): 2948–55. doi:10.4049/jimmunol.156.8.2948. PMID 8609432.
• Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (November 1996). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". The Journal of Biological Chemistry. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
• Koene HR, Kleijer M, Algra J, Roos D, von dem Borne AE, de Haas M (August 1997). "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype". Blood. 90 (3): 1109–14. doi:10.1182/blood.V90.3.1109. PMID 9242542.
• Nourse JP, Lea R, Crooks P, Wright G, Tran H, Catalano J, Brighton T, Grigg A, Marlton P, Gandhi MK (January 2012). "The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms". Blood Coagulation & Fibrinolysis. 23 (1): 45–50. doi:10.1097/mbc.0b013e32834d7ce3. PMID 22024796. S2CID 3327902.
• Keane C, Nourse JP, Crooks P, Nguyen-Van D, Mutsando H, Mollee P, Lea RA, Gandhi MK (October 2012). "Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma". Internal Medicine Journal. 42 (10): 1113–9. doi:10.1111/j.1445-5994.2011.02587.x. hdl:10072/50781. PMID 21883784. S2CID 24913630.

External links

• Overview of all the structural information available in the PDB for UniProt: P08637 (Low affinity immunoglobulin gamma Fc region receptor III-A) at the PDBe-KB.