FCER1G

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is gamma chain of high affinity IgE receptor. This protein is encoded by the FCER1G gene in humans.^[5]

FCER1G
Identifiers
Aliases	FCER1G, FCRG, Fc fragment of IgE receptor Ig, Fc epsilon receptor Ig
External IDs	OMIM: 147139; MGI: 95496; HomoloGene: 3029; GeneCards: FCER1G; OMA:FCER1G - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,215,234 bp[1] End 161,220,699 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.23 cM Start 171,057,141 bp[2] End 171,061,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte right lung upper lobe of left lung blood spleen bone marrow bone marrow cells right coronary artery gallbladder Top expressed in granulocyte tibiofemoral joint decidua calvaria stroma of bone marrow blood spleen mesenteric lymph nodes ankle joint dermis More reference expression data BioGPS n/a
Gene ontology Molecular function IgE receptor activity IgG binding protein binding IgE binding transmembrane signaling receptor activity protein homodimerization activity Cellular component integral component of membrane membrane plasma membrane Fc-epsilon receptor I complex external side of plasma membrane tertiary granule membrane ficolin-1-rich granule membrane integral component of plasma membrane cell surface Biological process mast cell activation positive regulation of phagocytosis Fc receptor mediated stimulatory signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of interleukin-10 production negative regulation of mast cell apoptotic process receptor internalization positive regulation of type IIa hypersensitivity neutrophil activation involved in immune response serotonin secretion by platelet stimulatory C-type lectin receptor signaling pathway blood coagulation cellular response to low-density lipoprotein particle stimulus positive regulation of mast cell degranulation neutrophil chemotaxis antigen processing and presentation of exogenous peptide antigen via MHC class I platelet activation cell surface receptor signaling pathway phagocytosis, engulfment positive regulation of immune response positive regulation of type I hypersensitivity defense response to bacterium immunoglobulin mediated immune response Fc-gamma receptor signaling pathway positive regulation of mast cell cytokine production positive regulation of interleukin-6 production regulation of immune response positive regulation of tumor necrosis factor production integrin-mediated signaling pathway regulation of platelet activation protein localization to plasma membrane positive regulation of type III hypersensitivity T cell differentiation involved in immune response leukocyte migration signal transduction innate immune response neutrophil degranulation protein homooligomerization Fc-epsilon receptor signaling pathway osteoclast differentiation interleukin-2 production positive regulation of protein localization to cell surface positive regulation of interleukin-4 production interleukin-3-mediated signaling pathway immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2207 14127 Ensembl ENSG00000158869 ENSMUSG00000058715 UniProt P30273 P20491 RefSeq (mRNA) NM_004106 NM_010185 RefSeq (protein) NP_004097 NP_034315 Location (UCSC) Chr 1: 161.22 – 161.22 Mb Chr 1: 171.06 – 171.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The high affinity IgE receptor, FcεRI, is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000158869 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058715 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide".

Further reading

• Tsuji M, Ezumi Y, Arai M, Takayama H (September 1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry. 272 (38): 23528–31. doi:10.1074/jbc.272.38.23528. PMID 9295288.
• Kihara H, Siraganian RP (September 1994). "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor". The Journal of Biological Chemistry. 269 (35): 22427–32. doi:10.1016/S0021-9258(17)31807-0. PMID 8071371.
• Huang L, Chen S, Zha X, Yang L, Li B, Yu Z, Wang L, Li Y (March 2012). "Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia". Hematology. 17 (2): 71–5. doi:10.1179/102453312X13221316477895. PMID 22664044. S2CID 24701040.
• Kim YK, Park HW, Yang JS, Oh SY, Chang YS, Shin ES, Lee JE, Kim S, Gho YS, Cho SH, Min KU, Kim YY (April 2007). "Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness". Clinical and Experimental Allergy. 37 (4): 592–8. doi:10.1111/j.1365-2222.2007.02680.x. PMID 17430357. S2CID 25869901.
• Zha X, Yan X, Shen Q, Zhang Y, Wu X, Chen S, Li B, Yang L, Geng S, Weng J, Du X, Li Y (December 2012). "Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia". Journal of Hematology & Oncology. 5: 74. doi:10.1186/1756-8722-5-74. PMC 3544630. PMID 23228155.
• Takahashi K, Hayashi N, Shimokawa T, Umehara N, Kaminogawa S, Ra C (May 2008). "Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1". The Journal of Biological Chemistry. 283 (22): 15134–41. doi:10.1074/jbc.M800498200. PMC 3258888. PMID 18378679.
• Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ (July 2012). "CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl". Journal of Immunology. 189 (2): 786–92. doi:10.4049/jimmunol.1200887. PMC 3665352. PMID 22706086.
• Gross BS, Melford SK, Watson SP (August 1999). "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". European Journal of Biochemistry. 263 (3): 612–23. doi:10.1046/j.1432-1327.1999.00560.x. PMID 10469124.
• Kumar P, Singh B, Lal R, Rembhotkar GW, Singh AB (2009). "Association between reduced levels of total serum IgE and FcepsilonRI expression in non-releaser basophils". Immunobiology. 214 (5): 377–83. doi:10.1016/j.imbio.2008.09.008. PMID 19362683.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.