FAM3B

Protein FAM3B is a protein that in humans is encoded by the FAM3B gene.^[5]

FAM3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YOP, 2YOQ
Identifiers
Aliases	FAM3B, 2-21, C21orf11, C21orf76, ORF9, PANDER, PRED44, family with sequence similarity 3 member B, FAM3 metabolism regulating signaling molecule B
External IDs	OMIM: 608617; MGI: 1270150; HomoloGene: 10766; GeneCards: FAM3B; OMA:FAM3B - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 41,304,212 bp[1] End 41,357,727 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 57.47 cM Start 97,272,165 bp[2] End 97,316,016 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum parotid gland jejunal mucosa duodenum body of pancreas pancreatic epithelial cell pancreatic ductal cell oral cavity olfactory zone of nasal mucosa corpus epididymis Top expressed in gastric mucosa epithelium of stomach pyloric antrum mucous cell of stomach seminal vesicula duodenum jejunum left colon intestinal villus seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity Cellular component extracellular region extracellular exosome extracellular space Biological process insulin secretion apoptotic process regulation of signaling receptor activity glucose homeostasis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54097 52793 Ensembl ENSG00000183844 ENSMUSG00000022938 UniProt P58499 Q9D309 RefSeq (mRNA) NM_058186 NM_206964 NM_020622 RefSeq (protein) NP_478066 NP_996847 NP_065647 Location (UCSC) Chr 21: 41.3 – 41.36 Mb Chr 16: 97.27 – 97.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• FAM3C
• FAM3D

References

1. GRCh38: Ensembl release 89: ENSG00000183844 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022938 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FAM3B family with sequence similarity 3, member B".

Further reading

• Yang J, Robert CE, Burkhardt BR, Young RA, Wu J, Gao Z, Wolf BA (November 2005). "Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells". Diabetes. 54 (11): 3217–28. doi:10.2337/diabetes.54.11.3217. PMID 16249448.
• Yang J, Gao Z, Robert CE, Burkhardt BR, Gaweska H, Wagner A, Wu J, Greene SR, Young RA, Wolf BA (August 2005). "Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells". Biochemistry. 44 (34): 11342–52. doi:10.1021/bi0503908. PMID 16114871.
• Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMID 12160727.
• Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (November 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Protein FAM3B