Exonuclease VII

The enzyme exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.^[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.^[3] that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.

Exonuclease VII, large subunit
Identifiers
Symbol	Exonuc_VII_L
Pfam	PF02601
InterPro	IPR020579
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Exonuclease VII small subunit
crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution
Identifiers
Symbol	Exonuc_VII_S
Pfam	PF02609
InterPro	IPR003761
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

References

1. Chase, J.W.; Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. doi:10.1016/S0021-9258(19)42453-8. PMID 4602029.
2. Chase, J.W.; Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. doi:10.1016/S0021-9258(19)42454-X. PMID 4602030.
3. Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. doi:10.1016/S0021-9258(18)34201-7. PMID 6284744.

This article incorporates text from the public domain Pfam and InterPro: IPR020579

This article incorporates text from the public domain Pfam and InterPro: IPR003761