Estradiol furoate

Estradiol furoate
Clinical data
Trade names	Di-Folliculine
Other names	EF; 17-Furoylestradiol; 17-(2-Furancarbonyl)estradiol
Routes of; administration	Intramuscular injection
Drug class	Estrogen; Estrogen ester
Identifiers
	IUPAC name [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate;
CAS Number	1083178-02-2 ;
PubChem CID	25111789;
ChemSpider	58838618;
UNII	WZW1I7J5RW;
CompTox Dashboard (EPA)	DTXSID001046411 ;
Chemical and physical data
Formula	C23H26O4
Molar mass	366.457 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2OC(=O)c5occc5;
	InChI InChI=1S/C23H26O4/c1-23-11-10-17-16-7-5-15(24)13-14(16)4-6-18(17)19(23)8-9-21(23)27-22(25)20-3-2-12-26-20/h2-3,5,7,12-13,17-19,21,24H,4,6,8-11H2,1H3/t17-,18-,19+,21+,23+/m1/s1; Key:UZMCMLLMBRERNY-BEARUUAKSA-N;

Estradiol furoate (EF), or estradiol 17β-furoate, sold under the brand name Di-Folliculine, is an estrogen medication and estrogen ester which is no longer marketed.^[1] It is the C17β furoate ester of estradiol.^[1] Estradiol benzoate has also been marketed under the brand name Di-Folliculine, and should not be confused with estradiol furoate.^[2]

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The duration of action of the related estradiol ester estradiol 3-furoate by intramuscular injection was studied in women in 1952.^[3] Its duration in oil solution was found to be similar to that of estradiol benzoate in oil solution and shorter than that of estradiol dipropionate in oil solution.^[3]

List of estrogen esters § Estradiol esters

[1]
Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 898. ISBN 978-1-4757-2085-3.
[2]
Pharmaceutical Abstracts. American Pharmaceutical Association. 1941. p. 149.
[3]
Ferin J (January 1952). "Relative duration of action of natural and synthetic estrogens administered parenterally in women with estrogen deficiency". The Journal of Clinical Endocrinology and Metabolism. 12 (1): 28–35. doi:10.1210/jcem-12-1-28. PMID 14907837.

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[Elks2014-1] [1]
Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 898. ISBN 978-1-4757-2085-3.

[APA1941-2] [2]
Pharmaceutical Abstracts. American Pharmaceutical Association. 1941. p. 149.

[Ferin1952-3] [3]
Ferin J (January 1952). "Relative duration of action of natural and synthetic estrogens administered parenterally in women with estrogen deficiency". The Journal of Clinical Endocrinology and Metabolism. 12 (1): 28–35. doi:10.1210/jcem-12-1-28. PMID 14907837.

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Estradiol furoate

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References