Ephrin A2

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.^[5]

EFNA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WO3
Identifiers
Aliases	EFNA2, ELF-1, EPLG6, HEK7-L, LERK-6, LERK6, ephrin A2
External IDs	OMIM: 602756; MGI: 102707; HomoloGene: 1075; GeneCards: EFNA2; OMA:EFNA2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,285,873 bp[1] End 1,301,431 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,015,316 bp[2] End 80,025,844 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon buccal mucosa cell mucosa of transverse colon pancreatic ductal cell jejunal mucosa gonad duodenum right lobe of liver sural nerve Top expressed in internal carotid artery external carotid artery Rostral migratory stream abdominal wall gastrula limb bud Gonadal ridge fossa condyle ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ephrin receptor binding protein binding Cellular component anchored component of membrane neuromuscular junction perikaryon membrane plasma membrane Biological process cell-cell signaling olfactory bulb development axon guidance osteoclast differentiation bone remodeling ephrin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1943 13637 Ensembl ENSG00000099617 ENSMUSG00000003070 UniProt O43921 P52801 RefSeq (mRNA) NM_001405 NM_007909 RefSeq (protein) NP_001396 NP_031935 Location (UCSC) Chr 19: 1.29 – 1.3 Mb Chr 10: 80.02 – 80.03 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.^[5]