Ependymin

Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene.

Ependymin Related 1
Identifiers
Symbol	EPDR1
Alt. symbols	EPDR, MERP1, UCC1
Alt. names	Mammalian Ependymin-Related Protein 1, Upregulated In Colorectal Cancer Gene 1 Protein
NCBI gene	54749
HGNC	17572
OMIM	619734
RefSeq	NM_017549.5
UniProt	Q9UM22
Other data
Locus	Chr. 7 p14.1
Wikidata	Q18041226
Search for Structures Swiss-model Domains InterPro

Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration.^[1] This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes.^[2] Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity,^[3] as well as behavioral performance in response to environment stress in fishes.^[4] For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion and migration processes in the central nervous system of teleost fishes.^[5] The presence of ependymin-related proteins can be found in both vertebrates and invertebrates.^[6] They have variety of functional roles in non-neural sites of organisms.^[6] For example, an ependymin-related gene that is upregulated in colon cancer known as UCC1 was found in human colorectal tumor cells.^[7]