Ependymin

Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene.

Ependymin Related 1
Identifiers
Symbol	EPDR1
Alt. symbols	EPDR, MERP1, UCC1
Alt. names	Mammalian Ependymin-Related Protein 1, Upregulated In Colorectal Cancer Gene 1 Protein
NCBI gene	54749
HGNC	17572
OMIM	619734
RefSeq	NM_017549.5
UniProt	Q9UM22
Other data
Locus	Chr. 7 p14.1
Wikidata	Q18041226
Search for Structures Swiss-model Domains InterPro

Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration.^[1] This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes.^[2] Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity,^[3] as well as behavioral performance in response to environment stress in fishes.^[4] For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion and migration processes in the central nervous system of teleost fishes.^[5] The presence of ependymin-related proteins can be found in both vertebrates and invertebrates.^[6] They have variety of functional roles in non-neural sites of organisms.^[6] For example, an ependymin-related gene that is upregulated in colon cancer known as UCC1 was found in human colorectal tumor cells.^[7]

References

1. Suárez-Castillo EC, García-Arrarás JE (February 2007). "Molecular evolution of the ependymin protein family: a necessary update". BMC Evolutionary Biology. 7: 23. doi:10.1186/1471-2148-7-23. PMC 1805737. PMID 17302986.
2. Shashoua VE (August 1991). "Ependymin, a brain extracellular glycoprotein, and CNS plasticity". Annals of the New York Academy of Sciences. 627 (1 Activity–Driv): 94–114. Bibcode:1991NYASA.627...94S. doi:10.1111/j.1749-6632.1991.tb25916.x. PMID 1831964. S2CID 37649781.
3. Pradel G, Schmidt R, Schachner M (June 2000). "Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish". Journal of Neurobiology. 43 (4): 389–403. doi:10.1002/1097-4695(20000615)43:4<389::aid-neu7>3.3.co;2-o. PMID 10861564.
4. Tang SJ, Sun KH, Sun GH, Lin G, Lin WW, Chuang MJ (October 1999). "Cold-induced ependymin expression in zebrafish and carp brain: implications for cold acclimation". FEBS Letters. 459 (1): 95–99. doi:10.1016/s0014-5793(99)01229-6. PMID 10508924. S2CID 29977014.
5. Garina DV (2021-01-01). "Ependymins: New Data on Participation in the Regulation of Physiological and Behavioral Responses in Teleosts (Review)". Inland Water Biology. 14 (1): 78–86. Bibcode:2021InWB...14...78G. doi:10.1134/S199508292101003X. ISSN 1995-0837. S2CID 232060615.
6. McDougall C, Hammond MJ, Dailey SC, Somorjai IM, Cummins SF, Degnan BM (December 2018). "The evolution of ependymin-related proteins". BMC Evolutionary Biology. 18 (1): 182. Bibcode:2018BMCEE..18..182M. doi:10.1186/s12862-018-1306-y. PMC 6280359. PMID 30514200.
7. Nimmrich I, Erdmann S, Melchers U, Chtarbova S, Finke U, Hentsch S, et al. (April 2001). "The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells". Cancer Letters. 165 (1): 71–79. doi:10.1016/S0304-3835(01)00390-1. PMID 11248421.

External links

• Smelick C. "Ependymin-dervied Drugs: Behind CereMedix's Absurd Claims". biologicalgerontology.com.