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German physician and physiologist (1818–1896) From Wikipedia, the free encyclopedia
Emil Heinrich du Bois-Reymond (7 November 1818 – 26 December 1896) was a German physiologist, the co-discoverer of nerve action potential, and the developer of experimental electrophysiology. His lectures on science and culture earned him great esteem during the latter half of the 19th century.[1]
Emil du Bois-Reymond | |
|---|---|
| |
| Born | Emil Heinrich du Bois-Reymond 7 November 1818 |
| Died | 26 December 1896 (aged 78) Berlin, Germany |
| Nationality | German |
| Alma mater | University of Berlin |
| Known for | Nerve action potential |
| Spouse(s) | Jeannette du Bois-Reymond, née Claude |
| Children | 9 |
| Scientific career | |
| Fields | |
| Doctoral advisor | Johannes Müller |
| Other academic advisors | Karl Bogislaus Reichert, Heinrich Wilhelm Dove, Gustav Magnus |
| Notable students | William James |
Du Bois-Reymond was born in Berlin and spent his life there. His younger brother was the mathematician Paul du Bois-Reymond (1831–1889). His father was a poor immigrant from Neuchâtel, and his mother was a Berliner of prominent Huguenot origin.[2][3]
Educated first at the French College in Berlin, du Bois-Reymond enrolled in the University of Berlin in 1838. He seems to have been uncertain at first as to the topic of his studies, for he was a student of the renowned ecclesiastical historian August Neander, and dallied with Naturphilosophie, geology, and physics, but eventually began to study medicine with such zeal and success as to attract the notice of Johannes Peter Müller (1801–1858), a well-known professor of anatomy and physiology.[2]
Müller's earlier studies had been distinctly physiological, but his preferences caused him later to study comparative anatomy. He had, about the time when the young du Bois-Reymond came to his lectures, published his Elements of Physiology, which contains the following statement:[4]
Though there appears to be something in the phenomena of living beings which cannot be explained by ordinary mechanical, physical or chemical laws, much may be so explained, and we may without fear push these explanations as far as we can, so long as we keep to the solid ground of observation and experiment.
In 1840 Müller made du Bois-Reymond his assistant in physiology, and as the beginning of an inquiry gave him a copy of the essay which the Italian physicist Carlo Matteucci had just published on the electric phenomena of animals.[5][6] This determined the work of du Bois-Reymond's life. He chose as the subject of his graduation thesis Electric fishes, and so commenced a long series of investigations on bioelectricity. The results of these inquiries were made known partly in papers communicated to scientific journals, but also and chiefly by his work Investigations of Animal Electricity,[7] the first part of which was published in 1848, the last in 1884.[4]
In 1852 while living alone and unable to get a professorship he traveled to England and met his second cousin Jeannette Claude, whom he courted and married in 1853.[8][9] The couple had ten children, one of whom died in infancy.
Concerning his religious opinions, du Bois-Reymond was an atheist or at best agnostic.[10]
Investigations of Animal Electricity may be seen in two ways. On the one hand, it is a record of the exact determination and approximative analysis of the electric phenomena presented by living beings. Viewed from this standpoint, it represents a significant advance in biological knowledge. Du Bois-Reymond built up this branch of science, by inventing or improving methods, by devising new instruments of observation, or by adapting old ones. On the other hand, the volumes in question contain an exposition of a theory of bioelectricity. In them Du Bois-Reymond put forward a general conception that a living tissue, such as muscle, might be regarded as composed of a number of electric molecules, and that the electric behavior of the muscle was the product of these elementary units.[4] We now know that these are sodium, potassium and other ions, the gradients of which are responsible for maintaining membrane potentials in excitable cells.[citation needed]
His theory was soon criticized by several contemporary physiologists, such as Ludimar Hermann, who maintained that intact living tissue such as muscle does not generate electric currents unless it has suffered injury.[11] The subsequent controversy was ultimately resolved in 1902 by du Bois-Reymond's student Julius Bernstein, who incorporated parts of both theories into an ionic model of action potential.[12][13] Thus, du Bois-Reymond's work focused on animal electricity, although he made other physiological inquiries — such as could be studied by physical methods — concerning the phenomena of diffusion, the muscular production of lactic acid, and the development of shocks by electric fishes.
Du Bois-Reymond exerted great influence as a teacher.[14] In 1858, upon the death of Johannes Müller, the professorship of anatomy and physiology at the University of Berlin was divided into a professorship of human and comparative anatomy, which was given to Karl Bogislaus Reichert (1811–1883), and a professorship of physiology, which was given to du Bois-Reymond. This he held until his death, performing research for many years without adequate accommodation. In 1877, the Prussian government granted his wish and provided the university with a modern physiological laboratory.
In 1851 du Bois-Reymond was admitted to the Academy of Sciences of Berlin, and in 1876 he became its perpetual secretary.[4] Like his friend Hermann von Helmholtz, who had also studied under Johannes Peter Müller, du Bois-Reymond was known throughout Germany. He used his influence for the advancement of science, introducing the theories of thermodynamics and Darwin to students at the University of Berlin.[4][15] He owed the largest part of his fame, however, to occasional discourses on literature, history, and philosophy.
Following France's declaration of war on Prussia on 3 August 1870, du Bois-Reymond proclaimed that "the University of Berlin, quartered opposite the King's palace, is, by the deed of its foundation, the intellectual bodyguard (geistige Leibregiment) of the House of Hohenzollern."[16] But by the time of France's surrender on 26 January 1871 du Bois-Reymond had come to regret his words, lamenting the "national hatred of two embittered peoples."[17] His 1878 lecture "On National Feeling" expanded on this topic, offering one of the earliest analyses of nationalism after those of Lord Acton and Fustel de Coulanges.[18]
In 1877 du Bois-Reymond presented a view of the past that highlighted science as the sole endeavor that demonstrated any improvement. "Science is the chief instrument of civilization," he wrote, "and the history of science the essential history of humanity.”[19] In 1936 his argument was repeated by George Sarton in a lecture inaugurating a seminary in the history of science at Harvard University:
Definition. Science is systematized positive knowledge, or what has been taken as such at different ages and in different places.
Theorem. The acquisition and systematization of positive knowledge are the only human activities which are truly cumulative and progressive.
Corollary. The history of science is the only history which can illustrate the progress of mankind. In fact, progress has no definite and unquestionable meaning in other fields than the field of science.[20]
One historiographer described du Bois-Reymond's attention to the history of science as "the first and indeed the most decisive attack on established historical scholarship" in the 19th century.[21]
Du Bois-Reymond was the first German professor to convert to Darwinism.[22] He expounded the theory in popular classes at the University of Berlin, in itinerant lectures in the Ruhr and the Rhineland, and in formal addresses translated and reprinted across Europe and North America. Unlike his rival Ernst Haeckel, du Bois-Reymond espoused a mechanistic interpretation of natural selection that anticipated modern views.[23] Few in Germany took offense at his teachings until 1883, when his obituary to Darwin outraged conservatives and Catholics.[24]
In 1880 du Bois-Reymond delivered a speech to the Berlin Academy of Sciences enumerating seven "world riddles" or "shortcomings" of science:[25]
Concerning numbers 1, 2 and 5 he proclaimed "Ignorabimus" ("we will never know"). Concerning number 7 he proclaimed "Dubitemus" ("we doubt it').
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