Emapunil

Emapunil (AC-5216, XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.^[1][2] This protein has multiple functions, among which is regulation of steroidogenesis,^[3][4] particularly the production of neuroactive steroids such as allopregnanolone in the brain.^[5][6][7] In both animal and human trials, emapunil produced fast acting anxiolytic and anti-panic effects, without producing sedation or withdrawal symptoms following cessation of use.^[8][9] Emapunil is also used in its ¹¹C radiolabelled form to map the distribution of TSPO receptors in the brain.^[10][11]

Emapunil

Clinical data
ATC code	none
Identifiers
IUPAC name N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide
CAS Number	226954-04-7
PubChem CID	6433109
ChemSpider	4938297
UNII	OG837L732J
ChEMBL	ChEMBL513922
CompTox Dashboard (EPA)	DTXSID40177220
Chemical and physical data
Formula	C23H23N5O2
Molar mass	401.470 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(Cc1ccccc1)C(=O)Cn2c3c(cnc(n3)c4ccccc4)n(c2=O)C
InChI InChI=1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3 Key:NBMBIEOUVBHEBM-UHFFFAOYSA-N
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See also

• SSR-180,575