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Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia
Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.[3][4][5]
PI3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | PI3, ESI, SKALP, WAP3, WFDC14, cementoin, peptidase inhibitor 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 182257; HomoloGene: 122140; GeneCards: PI3; OMA:PI3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[5]
Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.[6]
Elafin plays some role in gut inflammation. [7]
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