EPHA6

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.^[5][6]

EPHA6
Identifiers
Aliases	EPHA6, EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066, EPH receptor A6
External IDs	OMIM: 600066; MGI: 108034; HomoloGene: 56396; GeneCards: EPHA6; OMA:EPHA6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q11.2 Start 96,814,581 bp[1] End 97,761,532 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.3 Start 59,473,846 bp[2] End 60,425,894 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle gonad muscle layer of sigmoid colon stromal cell of endometrium Achilles tendon prefrontal cortex left ovary Top expressed in dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion Region I of hippocampus proper hippocampus proper primary visual cortex superior frontal gyrus zygote CA3 field tongue cartilage of the septum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity molecular function receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane nucleoplasm cellular component cytoplasm neuron projection receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway biological process negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285220 13840 Ensembl ENSG00000080224 ENSMUSG00000055540 UniProt Q9UF33 Q62413 RefSeq (mRNA) NM_001080448 NM_001278300 NM_001278301 NM_173655 NM_007938 RefSeq (protein) NP_001073917 NP_001265229 NP_001265230 NP_775926 NP_031964 Location (UCSC) Chr 3: 96.81 – 97.76 Mb Chr 16: 59.47 – 60.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer, particularly in patients with steroid receptor negative expression and HER‑2 overexpression^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000080224 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055540 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
6. "Entrez Gene: EPHA6 EPH receptor A6".
7. Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018). "Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer". Oncology Letters. 15 (4): 5257–5263. doi:10.3892/ol.2018.7919. PMC 5840743. PMID 29552165.

Further reading

• Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly. International Review of Cytology. Vol. 196. pp. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. {{cite book}}: |journal= ignored (help)
• Xu Q, Mellitzer G, Wilkinson DG (July 2000). "Roles of Eph receptors and ephrins in segmental patterning". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Nakamoto T, Kain KH, Ginsberg MH (February 2004). "Neurobiology: New connections between integrins and axon guidance". Current Biology. 14 (3): R121-3. Bibcode:2004CBio...14.R121N. doi:10.1016/j.cub.2004.01.020. PMID 14986683. S2CID 2957639.
• Yamaguchi Y, Pasquale EB (June 2004). "Eph receptors in the adult brain". Current Opinion in Neurobiology. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108. S2CID 26196696.
• Murai KK, Pasquale EB (August 2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258. S2CID 23900846.
• Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, et al. (July 1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
• Aasheim HC, Munthe E, Funderud S, Smeland EB, Beiske K, Logtenberg T (January 2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood. 95 (1): 221–30. doi:10.1182/blood.V95.1.221. PMID 10607706.
• Prevost N, Woulfe D, Tanaka T, Brass LF (July 2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred". Proceedings of the National Academy of Sciences of the United States of America. 99 (14): 9219–24. Bibcode:2002PNAS...99.9219P. doi:10.1073/pnas.142053899. PMC 123121. PMID 12084815.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, et al. (March 2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers". Clinical Chemistry. 50 (3): 490–9. doi:10.1373/clinchem.2003.026849. PMID 14726470.

External links

• Overview of all the structural information available in the PDB for UniProt: Q62413 (Mouse Ephrin type-A receptor 6) at the PDBe-KB.