EMDT

Chemical compound From Wikipedia, the free encyclopedia

EMDT

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor.[1][2] Its affinities for many other targets have also been reported.[2] EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885.[3] Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.[4]

Quick Facts Clinical data, Other names ...
EMDT
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Clinical data
Other names2-Ethyl-5-methoxy-N,N-dimethyltryptamine; 2-Ethyl-5-MeO-DMT; 2-Et-5-MeO-DMT
ATC code
  • none
Identifiers
  • 2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H22N2O
Molar mass246.354 g·mol−1
3D model (JSmol)
  • CCc2[nH]c1ccc(OC)cc1c2CCN(C)C
  • InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3 N
  • Key:ZEYRDXUWJDGTLD-UHFFFAOYSA-N N
 NY (what is this?)  (verify)
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