ELP2

Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene.^[5][6][7]

ELP2
Identifiers
Aliases	ELP2, SHINC-2, STATIP1, StIP, elongator acetyltransferase complex subunit 2, MRT58
External IDs	OMIM: 616054; MGI: 1889642; HomoloGene: 6019; GeneCards: ELP2; OMA:ELP2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.2 Start 36,129,444 bp[1] End 36,180,557 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A2 Start 24,735,923 bp[2] End 24,772,564 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary Achilles tendon right ovary skin of abdomen ganglionic eminence skin of leg epithelium of colon right uterine tube body of pancreas canal of the cervix Top expressed in saccule otic placode motor neuron facial motor nucleus internal carotid artery condyle external carotid artery primitive streak utricle fossa More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II complex binding protein kinase binding Cellular component histone acetyltransferase complex transcription elongation factor complex nucleus cytoplasm cytosol elongator holoenzyme complex Biological process regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated regulation of receptor signaling pathway via JAK-STAT tRNA wobble uridine modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55250 58523 Ensembl ENSG00000134759 ENSMUSG00000024271 UniProt Q6IA86 Q91WG4 RefSeq (mRNA) NM_001242875 NM_001242876 NM_001242877 NM_001242878 NM_001242879 NM_018255 NM_001324465 NM_001324466 NM_001324467 NM_001324468 NM_001324469 NM_021448 NM_001360909 RefSeq (protein) NP_001229804 NP_001229805 NP_001229806 NP_001229807 NP_001229808 NP_001311394 NP_001311395 NP_001311396 NP_001311397 NP_060725 NP_067423 NP_001347838 Location (UCSC) Chr 18: 36.13 – 36.18 Mb Chr 18: 24.74 – 24.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ELP2 has been shown to interact with STAT3^[6] and Janus kinase 1.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024271 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
6. Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
7. "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.