EIF4H

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

EIF4H

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.[5][6][7]

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EIF4H
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4H, WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDsOMIM: 603431; MGI: 1341822; HomoloGene: 32536; GeneCards: EIF4H; OMA:EIF4H - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022170
NM_031992

NM_033561
NM_001312867

RefSeq (protein)

NP_071496
NP_114381

NP_001299796
NP_291039

Location (UCSC)Chr 7: 74.17 – 74.2 MbChr 5: 134.65 – 134.67 Mb
PubMed search[3][4]
Wikidata
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This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.[7]

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity.[8]

References

Further reading

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