EIF4G2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

EIF4G2

Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.[5][6]

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EIF4G2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4G2, AAG1, DAP5, NAT1, P97, eukaryotic translation initiation factor 4 gamma 2
External IDsOMIM: 602325; MGI: 109207; HomoloGene: 37477; GeneCards: EIF4G2; OMA:EIF4G2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001418
NM_001042559
NM_001172705

NM_001040131
NM_013507

RefSeq (protein)

NP_001036024
NP_001166176
NP_001409

NP_001035221
NP_038535

Location (UCSC)Chr 11: 10.8 – 10.81 MbChr 7: 110.67 – 110.68 Mb
PubMed search[3][4]
Wikidata
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Function

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by the eIF4G2 gene shares similarity with the C-terminal region of eIF4G1 that contains the binding sites for eIF4A and eIF3. eIF4G2 additionally contains a binding site for eIF4E at the N-terminus. Unlike eIF4G1, which supports cap-dependent and independent translation, the eIF4G2 gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[7]

Interactions

EIF4G2 has been shown to interact with EIF3A.[8][9]

References

Further reading

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