Dicirenone

Dicirenone (INN, USAN; developmental code name SC-26304; also known as 7α-carboxyisopropylspirolactone) is a synthetic, steroidal antimineralocorticoid of the spirolactone group which was developed as a diuretic and antihypertensive agent but was never marketed.^[1][2] It was synthesized and assayed in 1974.^[1] Similarly to other spirolactones like spironolactone, dicirenone also possesses antiandrogen activity, albeit with relatively reduced affinity.^[3]

Dicirenone

Clinical data
Other names	SC-26304; 7α-Carboxyisopropylspirolactone; 17α-Hydroxy-3-oxopregn-4-ene-7α,21-dicarboxylic acid γ-lactone 1-isopropyl ester
Routes of administration	Oral
Identifiers
IUPAC name Propan-2-yl (7R,8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-carboxylate
CAS Number	41020-79-5
PubChem CID	10387872
ChemSpider	8563314
UNII	M8K306YKSX
KEGG	D03792
ChEMBL	ChEMBL2106258
CompTox Dashboard (EPA)	DTXSID101023456
Chemical and physical data
Formula	C26H36O5
Molar mass	428.569 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)OC(=O)[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
InChI InChI=1S/C26H36O5/c1-15(2)30-23(29)18-14-16-13-17(27)5-9-24(16,3)19-6-10-25(4)20(22(18)19)7-11-26(25)12-8-21(28)31-26/h13,15,18-20,22H,5-12,14H2,1-4H3/t18-,19+,20+,22-,24+,25+,26-/m1/s1 Key:WUVPAYPBMZMHJO-IMNLCBETSA-N