Del Valle is a topographic surname[1] literally meaning "from the valley" in Spanish. Notable people with the surname include:
- Aaron del Valle, Chicago Police officer and politician
- Ada Itúrrez de Cappellini or Ada Rosa del Valle Itúrrez de Cappellini, an Argentine politician
- Agripina Montes del Valle (c. 1844–1912), Colombian poet, writer, and intellectual
- Andrés del Valle (1833–1888), former President of El Salvador
- Antonio del Valle Toca, Mexican politician
- Ana Isabel de Palacio y del Valle Lersundi or Ana Palacio, Spanish lawyer and politician, former Spain's minister for foreign affairs
- Andreina del Valle Pinto Pérez or Andreina Pinto, Olympic and National record holding swimmer from Venezuela
- Antonio del Valle Ruiz, Mexican businessman
- Alexandre del Valle (born 1968), Franco-Italian politologist, writer, professor, columnist, and political commentator
- Argentino del Valle Larrabure (1932–1975), Argentine military officer
- Aristóbulo del Valle (15 March 1845 – 29 January 1896), Argentinian lawyer and politician
- Agustín Salas del Valle, Mexican serial murderer
- Ayron del Valle, Colombian professional footballer
- Carlos Yushimito del Valle, Peruvian writer of Japanese descent
- Cristina del Valle, Spanish singer and activist
- Danielys Del Valle García Buitrago, female track and road cyclist from Venezuela
- David Del Valle, journalist, columnist, film historian, and radio and television commentator on horror, science-fiction, cult and fantasy films
- David García del Valle, judo paralympic athlete from Spain
- Dennis Del Valle (born 1989), Puerto Rican volleyball player
- Desiree del Valle, Filipina actress
- Emilio del Valle Escalante or Emil' Keme, Guatemalan/K'iche Maya professor and researcher in Indigenous literatures
- Emilio del Valle, Spanish politician
- Emilio Menéndez del Valle, Spanish politician
- Enrique del Valle, Ecuadorian judoka
- Estrella del Valle, Mexican poet
- Fe del Valle, Cuban civil rights activist
- Fernando Alfonso Yznaga del Valle or Fernando Yznaga (1850 – 1901), Cuban American banker
- Fernando del Valle, American operatic tenor
- Gabriel del Valle, Argentine football manager and former player
- Gladys del Valle Requena, Venezuelan politician
- Guillermo León Teillier del Valle or Guillermo Teillier (29 October 1943 – 29 August 2023) was a Chilean politician, educator, and writer
- Guillermo del Valle, Mexican politician
- Ignacia de Loyola de Palacio y del Valle Lersundi or Loyola de Palacio (1950–2006), Spanish politician
- José Cecilio Díaz del Valle (November 22, 1780 – March 2, 1834) was a philosopher, politician, lawyer, and journalist
- Juan Carlos del Valle, Mexican painter
- Juan del Valle (died 1563) was a Roman Catholic prelate
- Juan del Valle y Caviedes (1645–1698), Colonial poet from Viceregal Peru
- Jorge del Valle, Cuban water polo player
- Jorge Iván del Valle, Colombian human rights activist, open water swimmer and a graphic designer
- José de Jesús Angulo del Valle y Navarro (1888–1966), Mexican Roman Catholic bishop
- José Luis del Valle (19012-1983), Spanish lawyer
- Julio Rosado del Valle, Puerto Rican abstract expressionist
- Lilia del Valle (1928–2013), Mexican actress
- Lou Del Valle, American boxer
- Lucretia del Valle Grady (1892–1972), political activist, suffragette, and actress
- Luis Del Valle, Puerto Rican professional boxer
- Luisa del Valle Silva (1896–1962), Venezuelan poet
- María Colombo de Acevedo or María Teresita del Valle Colombo de Acevedo (1957 – 3 May 2021) was an Argentine politician
- Manuel Castro y del Valle, Mexican politician
- Manuel del Valle (1939–2020), Spanish lawyer, politician
- Manuela Vilar del Valle, Uruguayan field hockey player
- María Eugenia del Valle (1928–1994), Chilean-Bolivian historian, researcher, and university professor
- Maurice del Valle (1883–1965), French ice hockey player.
- María Remedios del Valle (ca. 1768–1847), Afro-Argentine camp follower turned soldier
- Martha Del Valle, Mexican dressage rider
- Martín del Valle, Peruvian badminton player
- Melissa Del Valle, American multiple champion in women's boxing
- Menchu Álvarez del Valle, Spanish radio journalist and paternal grandmother of the queen consort of Spain, Letizia Ortiz Rocasolano
- Miguel del Valle, American politician
- Nelson del Valle, Puerto Rican politician
- Pedro del Valle (1893–1978), USMC General
- Pedro Núñez del Valle (1597 – 1649) was a Spanish painter
- Pompeyo del Valle, Honduran poet and journalist
- Rafael del Valle (1908–1973), Chilean film and theatre actor
- Ramón del Valle-Inclán y de la Peña, Spanish dramatist, novelist
- Raúl del Valle (1908–1973),
- Rodulfo del Valle (1871–1948) was Mayor of Ponce, Puerto Rico
- Santiago del Valle, Mexican hacendado and government official
- Sara Del Valle, mathematical epidemiologist
- Sergio del Valle Jiménez (1927–2007), Cuban military and government official
- Stephanie Del Valle, Puerto Rican musician
- Teresa del Valle, Spanish anthropologist
- Ygnacio del Valle
- Yonathan Del Valle, Venezuelan professional footballer
- Ysabel del Valle
- Fictional
Iris Shagrir, "The Medieval Evolution of By-naming: Notions from the Latin Kingdom of Jerusalem", In Laudem Hierosolymitani (Shagrir, Ellenblum & Riley-Smith, eds.), Ashgate Publishing, 2007, pp. 49-59; p.55