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Medication From Wikipedia, the free encyclopedia
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria.[1][2] It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells.[2]
Clinical data | |
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Trade names | Voydeya |
Other names | ACH-4471 |
AHFS/Drugs.com | Monograph |
License data | |
Routes of administration | By mouth |
Drug class | Complement factor D inhibitor |
ATC code | |
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Identifiers | |
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CAS Number | |
DrugBank | |
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KEGG | |
ChEMBL | |
ECHA InfoCard | 100.398.865 |
Chemical and physical data | |
Formula | C6H3BrFN7O3 |
Molar mass | 320.038 g·mol−1 |
3D model (JSmol) | |
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The most common side effects include fever, headache, increased levels of liver enzymes (a sign of possible liver problems) and pain in the extremities (arms and legs).[2]
Danicopan was approved for medical use in Japan in January 2024,[4] in the United States in March 2024,[1][5] and in the European Union in April 2024.[2]
Danicopan is indicated as add-on therapy to ravulizumab or eculizumab for the treatment of extravascular hemolysis in adults with paroxysmal nocturnal hemoglobinuria.[1][2]
Danicopan was approved for medical use in Japan,[6] the United States,[1] and the European Union in 2024.[2]
In February 2024, the Committee for Medicinal Products for Human Use of the EMA adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Voydeya, intended as add-on therapy to ravulizumab or eculizumab for the treatment of residual hemolytic anemia in adults with paroxysmal nocturnal hemoglobinuria (PNH).[2][7] The applicant for this medicinal product is Alexion Europe.[2] Danicopan was approved for medical use in the European Union in April 2024.[2][3]
Danicopan is the international nonproprietary name.[8]
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