Dachshund (gene)

dachshund (dac) is a gene involved in the development of the arthropod compound eye^[1] which also plays a role in leg development.^[2] It is activated by the Distal-less (Dll) gene.^[3]

Dachshund
Identifiers
Organism	Drosophila melanogaster
Symbol	dac
UniProt	Q24030
Search for Structures Swiss-model Domains InterPro

Dachshund homologue (DACH1) regulates tumorigenesis in humans as a part of the Retinal Determination Gene Network (RDGN) complex, with cancer patients showing altered DACH1 expression.^[4] Its homologs form the SKI/SNO/DAC family (Pfam PF02437).

References

1. Mardon G, Solomon NM, Rubin GM (December 1994). "dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila". Development. 120 (12): 3473–86. doi:10.1242/dev.120.12.3473. PMID 7821215.
2. Gehring WJ, Ikeo K (September 1999). "Pax 6: mastering eye morphogenesis and eye evolution". Trends in Genetics. 15 (9): 371–7. doi:10.1016/S0168-9525(99)01776-X. PMID 10461206.
3. Estella C, Voutev R, Mann RS (2012-01-01). "A Dynamic Network of Morphogens and Transcription Factors Patterns the Fly Leg". Transcriptional Switches During Development. Current Topics in Developmental Biology. Vol. 98. pp. 173–98. doi:10.1016/B978-0-12-386499-4.00007-0. ISBN 9780123864994. PMC 3918458. PMID 22305163.
4. Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG (January 2010). "The Dachshund gene in development and hormone-responsive tumorigenesis". Trends in Endocrinology and Metabolism. 21 (1): 41–9. doi:10.1016/j.tem.2009.08.002. PMC 2818438. PMID 19896866.