DHPS

This article is about the gene coding for the enzyme deoxyhypusine synthase. For another enzyme commonly abbreviated DHPS, see Dihydropteroate synthetase. For other uses, see DHPS (disambiguation).

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.^[5][6]

DHPS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DHS, 1RLZ, 1ROZ, 1RQD
Identifiers
Aliases	DHPS, deoxyhypusine synthase, DHS, DS, MIG13, NEDSSWI
External IDs	OMIM: 600944; MGI: 2683592; HomoloGene: 1453; GeneCards: DHPS; OMA:DHPS - orthologs
EC number	2.5.1.46
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,675,717 bp[1] End 12,681,880 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 85,798,386 bp[2] End 85,801,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum ganglionic eminence primary visual cortex pituitary gland anterior pituitary right uterine tube left ovary prostate muscle of thigh prefrontal cortex Top expressed in embryo embryo superior frontal gyrus neural layer of retina aortic valve muscle of thigh ascending aorta supraoptic nucleus epiblast morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein binding identical protein binding deoxyhypusine synthase activity Cellular component cytosol cytoplasm Biological process protein homotetramerization protein biosynthesis positive regulation of T cell proliferation glucose homeostasis positive regulation of cell population proliferation spermidine metabolic process spermidine catabolic process peptidyl-lysine modification to peptidyl-hypusine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1725 330817 Ensembl ENSG00000095059 ENSMUSG00000060038 UniProt P49366 Q3TXU5 RefSeq (mRNA) NM_001206974 NM_001930 NM_013406 NM_001369691 NM_001369692 NM_001369693 NM_001039514 NM_201408 RefSeq (protein) NP_001193903 NP_001921 NP_037538 NP_001356620 NP_001356621 NP_001356622 NP_001034603 Location (UCSC) Chr 19: 12.68 – 12.68 Mb Chr 8: 85.8 – 85.8 Mb PubMed search [3] [4]
Wikidata
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The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A (EIF5A, EIF5A2). In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.^[6]