DEPTOR

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene.^[5]

DEPTOR
Identifiers
Aliases	DEPTOR, DEP.6, DEPDC6, DEP domain containing MTOR-interacting protein, DEP domain containing MTOR interacting protein
External IDs	OMIM: 612974; MGI: 2146322; HomoloGene: 32551; GeneCards: DEPTOR; OMA:DEPTOR - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.12 Start 119,873,717 bp[1] End 120,050,918 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D1|15 21.96 cM Start 54,975,713 bp[2] End 55,122,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland Skeletal muscle tissue of biceps brachii decidua glutes vastus lateralis muscle Skeletal muscle tissue of rectus abdominis triceps brachii muscle hair follicle gastrocnemius muscle deltoid muscle Top expressed in lacrimal gland parotid gland pyloric antrum median eminence triceps brachii muscle brown adipose tissue sternocleidomastoid muscle tunica adventitia of aorta vastus lateralis muscle zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component intracellular anatomical structure cytoplasm Biological process intracellular signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of cell size negative regulation of protein kinase activity negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64798 97998 Ensembl ENSG00000155792 ENSMUSG00000022419 UniProt Q8TB45 Q570Y9 RefSeq (mRNA) NM_022783 NM_001283012 NM_001037937 NM_145470 RefSeq (protein) NP_001269941 NP_073620 NP_001033026 NP_663445 Location (UCSC) Chr 8: 119.87 – 120.05 Mb Chr 15: 54.98 – 55.12 Mb PubMed search [3] [4]
Wikidata
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Structure

The gene DEPTOR can be found only in vertebrates. In human, DEPTOR gene locates at chromosome 8, 8q24.12 with protein size 409 a.a.^[6] Human DEPTOR contains two N-terminal DEP domains and a C-terminal PDZ domain.^[7]

Function

DEPTOR is involved in mTOR signaling pathway as an endogenous regulator. A direct interaction between DEPTOR and mTOR has been shown. ^[7] Overexpression of DEPTOR downregulates the activity of mTORC1 and mTORC2 in vitro. mTORC1 and mTORC2 can both inhibit DEPTOR through phosphorylation.^[7]

Metabolism

DEPTOR cell-autonomously regulates adipogenesis.^[8] In the muscle, Baf60c promotes a switch from oxidative to glycolytic myofiber type through DEPTOR-mediated Akt/PKB activation.^[9] Within the brain, DEPTOR is highly expressed in the hippocampus, the medio-basal hypothalamus and the circumventricular organs.^[10] Overexpression of DEPTOR in the medio-basal hypothalamus protects mice against high-fat diet-induced obesity by modulating Akt/PKB signaling.^[11]

Clinical cancer

Although in most cancer, mTOR pathway is constitutively activated and the expression of DEPTOR is low, one study has found that DEPTOR is overexpressed in multiple myeloma cells and is necessary for their survival.^[7]