DAPK3

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.^[5][6]

DAPK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YRP, 2J90, 3BHY, 3BQR, 5A6O, 5A6N
Identifiers
Aliases	DAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDs	OMIM: 603289; MGI: 1203520; HomoloGene: 20353; GeneCards: DAPK3; OMA:DAPK3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,958,453 bp[1] End 3,971,123 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,018,839 bp[2] End 81,029,031 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastric mucosa popliteal artery tibial arteries ascending aorta stromal cell of endometrium right auricle muscle layer of sigmoid colon muscle of thigh body of uterus Top expressed in yolk sac muscle of thigh lip right kidney superior frontal gyrus primary visual cortex granulocyte spermatocyte dentate gyrus of hippocampal formation granule cell ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity cAMP response element binding protein binding kinase activity protein serine/threonine kinase activity leucine zipper domain binding protein binding identical protein binding ATP binding protein C-terminus binding Cellular component PML body actin filament membrane raft nucleus cytoplasm Biological process regulation of apoptotic process regulation of actin cytoskeleton reorganization negative regulation of translation intracellular signal transduction regulation of transcription, DNA-templated regulation of smooth muscle contraction phosphorylation positive regulation of cell migration positive regulation of canonical Wnt signaling pathway regulation of myosin II filament organization transcription, DNA-templated regulation of cell motility protein phosphorylation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of autophagy neuron differentiation regulation of mitotic cell cycle regulation of cell shape positive regulation of apoptotic process regulation of focal adhesion assembly cellular response to interferon-gamma apoptotic signaling pathway protein autophosphorylation regulation of translation regulation of mitotic nuclear division apoptotic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1613 13144 Ensembl ENSG00000167657 ENSMUSG00000034974 UniProt O43293 O54784 RefSeq (mRNA) NM_001348 NM_001375658 NM_001190473 NM_001190474 NM_007828 RefSeq (protein) NP_001339 NP_001362587 NP_001177402 NP_001177403 NP_031854 Location (UCSC) Chr 19: 3.96 – 3.97 Mb Chr 10: 81.02 – 81.03 Mb PubMed search [3] [4]
Wikidata
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Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.^[6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.^[7]

Interactions

DAPK3 has been shown to interact with PAWR^[8] and Death associated protein 6.^[8]