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Peripheral nerve disorder From Wikipedia, the free encyclopedia
Cramp fasciculation syndrome (CFS) is a rare[1] peripheral nerve hyperexcitability disorder. It is more severe than the related (and common) disorder known as benign fasciculation syndrome; it causes fasciculations, cramps, pain, fatigue, and muscle stiffness similar to those seen in neuromyotonia (another related condition).[2] Patients with CFS, like those with neuromyotonia, may also experience paresthesias.[3] Most cases of cramp fasciculation syndrome are idiopathic.[4]
Cramp fasciculation syndrome is diagnosed by clinical examination and electromyography (EMG).[5] Fasciculation is the only abnormality[6] (if any)[7] seen with EMG. Cramp fasciculation syndrome is a chronic condition.[8] Treatment options include anti-seizure medications such as carbamazepine, immunosuppressive drugs and plasmapheresis.[4]
Symptoms are very similar to those found in benign fasciculation syndrome and include:[9]
The procedure of diagnosis for Cramp Fasciculation Syndrome (CFS) is closely aligned with the diagnosis procedure for benign fasciculation syndrome (BFS). The differentiation between a diagnosis of BFS versus CFS is usually more severe and prominent pain, cramps and stiffness associated with CFS.[citation needed]
Treatment is similar to treatment for benign fasciculation syndrome.[citation needed]
Carbamazepine therapy has been found to provide moderate reductions in symptoms.[9]
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