Collecting duct carcinoma

Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers.^[2] It is also recently described; a 2002 review found just 40 case reports worldwide.^[3] Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma.^[4] However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly.

Collecting duct carcinoma
Other names	Bellini duct carcinoma[1]
Collecting duct carcinoma. H&E stain.
Specialty	Oncology/nephrology

Collecting duct carcinoma in computed tomography

Signs and symptoms

Signs and symptoms are as for kidney cancer.^{[citation needed]}

Histology

Histologic examination of collecting duct carcinoma demonstrates an infiltrative lesion with tubulopapillary, irregular channels lined by high grade hobnail cells with marked desmoplastic response and brisk neutrophilic infiltrate.^{[citation needed]}

Treatment

History

CDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.^[5]