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Stimulant drug used as an appetite suppressant From Wikipedia, the free encyclopedia
Clobenzorex (Asenlix, Dinintel, Finedal, Rexigen) is a stimulant drug of the amphetamine chemical class used as an appetite suppressant.[2] The drug is legally distributed in Mexico under the trade name Asenlix by Aventis.
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Other names | N-(2-chlorobenzyl)amphetamine |
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Routes of administration | Oral |
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ECHA InfoCard | 100.033.108 |
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Formula | C16H18ClN |
Molar mass | 259.78 g·mol−1 |
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Chemically, clobenzorex is an N-substituted amphetamine prodrug that is metabolized primarily into 4-hydroxyclobenzorex after ingestion; however, small amounts are also metabolized into dextroamphetamine.[3] In commercial production, clobenzorex is supplied as the hydrochloride salt in green-tinted capsules. The drug gained use as a prescription anorectic in the 1970s.
Condensation between amphetamine (1) and 2-chlorobenzaldehyde (2) gives a Schiff-base, CID:135056236 (3). Subsequent reduction with sodium borohydride completed the synthesis of clobenzorex (4).
Clobenzorex can be detected in urine, which can cause false positives for workplace drug screening.[7] It is one of many drugs that can cause false positives for amphetamine urine drug screening.[8] It may be differentiated from amphetamine use through testing for metabolites such as 4-hydroxyclobenzorex[9] or enantiomeric analysis.[7]
In Canada, Clobenzorex is not specifically listed in the CDSA, however due to structural similarity with nor benzphetamine, it is schedule I under item 19(17).[citation needed]
In the UK it is a controlled drug (class B).[10] In Brazil it's a controlled prohibited psychotropic (class A3).[11]
The substance is not scheduled in the United States and is unaffected by the Federal Analogue Act as a derivative of Benzphetamine. Clobenzorex is legal in the United States of America. [12]
Clobenzorex is not controlled within the United States or subject to import controls. Importation of clobenzorex for personal use is lawful provided that is for use to treat a condition with no approved medications, unlawful marketing is not occurring in the U.S, not deemed hazardous to health for the treating the condition, and is verified as a continuation of a treatment plan that began in a foreign country.[13]
The use of clobenzorex is banned by the World Anti-Doping Agency for use during sports competitions.[14]
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