Clobenzorex
Stimulant drug used as an appetite suppressant From Wikipedia, the free encyclopedia
Clobenzorex (primarily branded Asenlix) is a stimulant drug of the amphetamine chemical class in use since the 1970s as an anorectic and appetite suppressant.[2]
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| Other names | N-(2-chlorobenzyl)amphetamine |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| ECHA InfoCard | 100.033.108 |
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| Formula | C16H18ClN |
| Molar mass | 259.78 g·mol−1 |
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The drug is legally distributed in Mexico under the trade name Asenlix' (manufactured by Aventis), although generic brands exist includingDinintel, Finedal, Rexigen, and Ivotril).
Chemistry
Chemically, clobenzorex is an N-substituted amphetamine prodrug that is metabolized primarily into 4-hydroxyclobenzorex after ingestion, with small amounts also metabolized into dextroamphetamine.[3] In commercial production, clobenzorex is supplied as the hydrochloride salt in green-tinted capsules.
Synthesis
Condensation between amphetamine (1) and 2-chlorobenzaldehyde (2) gives a Schiff-base, CID:135056236 (3). Subsequent reduction with sodium borohydride completed the synthesis of clobenzorex (4).
Detection in urine
Clobenzorex can be detected in urine, which can cause false positives for workplace drug screening.[7] It is one of many drugs that can cause false positives for amphetamine urine drug screening.[8] It may be differentiated from amphetamine use through testing for metabolites such as 4-hydroxyclobenzorex[9] or enantiomeric analysis.[7]
Recreational use
The use of clobenzorex is banned by the World Anti-Doping Agency for use during sports competitions.[10]
Legal Status
Summarize
Perspective
United States of America
Clobenzorex is legal in the United States for personal possession,[11] as it is not specifically restricted by the Controlled Substances Act of 1970, nor is it regulated as a derivative of benzphetamine under the Federal Analogue Act.
Clobenzorex is not approved for medical use by the U.S. Food and Drug Administration, and hence is neither prescribed nor available for sale over the counter or behind the counter, as is the case with sales of ephedrine and pseudoephedrine products in the U.S. since 2006.
U.S. Customs and Border Patrol does not control or limit imports of clobenzorex for personal when alternative approved treatments are unavailable; or in the case of an orphan drug, often obscure, rarely stocked, or limited in quantity, if not unavailable. Likewise, the U.S. Drug Enforcement Administration does not interfere in the personal use of clobenzorex when the medication has been prescribed or refilled by a foreign-licensed health care provider or dispensed at a non-U.S. pharmacy. [dead link][citation needed]
Canada
In Canada, clobenzorex is not specifically listed in the CDSA, however due to structural similarity with nor benzphetamine, it is schedule I under item 19(17).[citation needed]
United Kingdom
In the United Kingdom, clobenzorex is a Class B controlled drug.[12] In Brazil it's a controlled prohibited psychotropic (class A3).[13]
See also
References
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