Climazolam

Climazolam^[1] (Ro21-3982) was introduced under licence as a veterinary medicine by the Swiss Pharmaceutical company Gräub under the tradename Climasol.^[2] Climazolam is a benzodiazepine, specifically an imidazobenzodiazepine derivative developed by Hoffman-LaRoche. It is similar in structure to midazolam and diclazepam and is used in veterinary medicine for anesthetizing animals.^[3][4]

Climazolam

Clinical data
Trade names	Climasol
AHFS/Drugs.com	International Drug Names
ATCvet code	QN05CD90 (WHO)
Legal status
Legal status	CA: Schedule IV
Identifiers
IUPAC name 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
CAS Number	59467-77-5
PubChem CID	68790
ChemSpider	62030
UNII	O9KZB9HG1Y
KEGG	D07714
ChEMBL	ChEMBL2104070
CompTox Dashboard (EPA)	DTXSID30208173
Chemical and physical data
Formula	C18H13Cl2N3
Molar mass	342.22 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC=CC=C1C2=NCC3=CN=C(C)N3C4=C2C=C(C=C4)Cl

References

1. US 4280957, Walser A, Fryer RI, "Imidazodiazepines and processes therefor", issued 28 July 1981, assigned to Hoffman La Roche
2. "Climazolam". Drugs.com. Archived from the original on 2017-08-01. Retrieved 2018-01-23.
3. Ganter M, Kanngiesser M (Aug 1991). "Effect of ketamine and its combinations with xylazine and climazolam on the circulation and respiration in swine". Zentralbl Veterinarmed A (in German). 38 (7): 501–509. doi:10.1111/j.1439-0442.1991.tb01041.x. PMID 1950241.
4. Bettschart-Wolfensberger R, Taylor PM, Sear JW, Bloomfield MR, Rentsch K, Dawling S (Oct 1996). "Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine". American Journal of Veterinary Research. 57 (10): 1472–1477. PMID 8896687.