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Chemical compound From Wikipedia, the free encyclopedia
Ciclazindol (WY-23409) is an antidepressant and anorectic[2] drug of the tetracyclic[citation needed] chemical class that was developed in the mid to late 1970s, but was never marketed.[3][4] It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor.[3][5] Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor.[5][6][7] As suggested by its local anesthetic properties,[6] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.[8][9]
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Routes of administration | Oral |
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Metabolism | Renal[1] |
Elimination half-life | ~32 hours[1] |
Excretion | Urine, feces[1] |
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Formula | C17H15ClN2O |
Molar mass | 298.77 g·mol−1 |
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The dosage in human volunteers is stated to be 25mg daily.[1] However, doses of up to 200mg have also been reported.[2] This is surprising since the dosage of mazindol is only 2-4mg per day.
Ciclazindol is reported to have an IC50 of 1.3nM for the dopamine transporter (cmp 23).[10]
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