Central chromatolysis

Central chromatolysis is a histopathologic change seen in the cell body of a neuron, where the chromatin and cell nucleus are pushed to the cell periphery, in response to axonal injury.^[1][2] This response is associated with increased protein synthesis to accommodate for axonal sprouting. In addition to traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra^[3]).

Micrograph of the anterior horn of the spinal cord showing motor neurons with central chromatolysis. H&E stain.

Micrograph of the anterior horn of the spinal cord showing motor neurons with central chromatolysis. Neurofilament immunostain.

See also

• Motor neuron