Calcipressin

In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.^[1]

Calcipressin
solution structure of rrm domain in calcipressin 1
Identifiers
Symbol	Calcipressin
Pfam	PF04847
Pfam clan	CL0221
InterPro	IPR006931
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In humans, the Calcipressins family of proteins is derived from three genes:

• Calcipressin 1 (encoded by RCAN1) is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1).
• Calcipressin 2 (encoded by RCAN2) is variously known as MCIP2, ZAKI-4 and DSCR1-like 1.
• Calcipressin 3 (encoded by RCAN3) is also called MCIP3 and DSCR1-like 2.^[2]

References

1. Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M (September 2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J. 374 (Pt 2): 567–75. doi:10.1042/BJ20030267. PMC 1223619. PMID 12809556.
2. Parry RV, June CH (September 2003). "Calcium-independent calcineurin regulation". Nat. Immunol. 4 (9): 821–3. doi:10.1038/ni0903-821. PMID 12942079. S2CID 7858766.

This article incorporates text from the public domain Pfam and InterPro: IPR006931