CYP26C1

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.^[5]

CYP26C1
Identifiers
Aliases	CYP26C1, FFDD4, cytochrome P450 family 26 subfamily C member 1
External IDs	OMIM: 608428; MGI: 2679699; HomoloGene: 28089; GeneCards: CYP26C1; OMA:CYP26C1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 93,060,798 bp[1] End 93,069,540 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 37,674,029 bp[2] End 37,681,846 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad prefrontal cortex olfactory zone of nasal mucosa placenta spleen myometrium substantia nigra C1 segment hippocampus proper Hypothalamus Top expressed in pharyngeal arch tail of embryo embryo embryo desmocranium amnion tongue enamel organ maxillary prominence surface ectoderm More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding oxidoreductase activity retinoic acid binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity retinoic acid 4-hydroxylase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane Biological process negative regulation of retinoic acid receptor signaling pathway central nervous system development retinoic acid catabolic process organelle fusion vitamin metabolic process neural crest cell development anterior/posterior pattern specification sterol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340665 546726 Ensembl ENSG00000187553 ENSMUSG00000062432 UniProt Q6V0L0 B2RXA7 RefSeq (mRNA) NM_183374 NM_001105201 RefSeq (protein) NP_899230 NP_001098671 Location (UCSC) Chr 10: 93.06 – 93.07 Mb Chr 19: 37.67 – 37.68 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.^[6]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.^[7]