CYP26C1

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.^[5]

CYP26C1
Identifiers
Aliases	CYP26C1, FFDD4, cytochrome P450 family 26 subfamily C member 1
External IDs	OMIM: 608428; MGI: 2679699; HomoloGene: 28089; GeneCards: CYP26C1; OMA:CYP26C1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 93,060,798 bp[1] End 93,069,540 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 37,674,029 bp[2] End 37,681,846 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad prefrontal cortex olfactory zone of nasal mucosa placenta spleen myometrium substantia nigra C1 segment hippocampus proper hypothalamus Top expressed in pharyngeal arch tail of embryo embryo embryo desmocranium amnion tongue Enamel organ maxillary prominence surface ectoderm More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding oxidoreductase activity retinoic acid binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity retinoic acid 4-hydroxylase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane Biological process negative regulation of retinoic acid receptor signaling pathway central nervous system development retinoic acid catabolic process organelle fusion vitamin metabolic process neural crest cell development anterior/posterior pattern specification sterol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340665 546726 Ensembl ENSG00000187553 ENSMUSG00000062432 UniProt Q6V0L0 B2RXA7 RefSeq (mRNA) NM_183374 NM_001105201 RefSeq (protein) NP_899230 NP_001098671 Location (UCSC) Chr 10: 93.06 – 93.07 Mb Chr 19: 37.67 – 37.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.^[6]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000187553 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062432 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297.
6.  This article incorporates public domain material from "Entrez Gene: CYP26C1". Reference Sequence collection. National Center for Biotechnology Information.
7. Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9 (3): e90776. Bibcode:2014PLoSO...990776B. doi:10.1371/journal.pone.0090776. PMC 3946526. PMID 24608339.

External links

• Human CYP26C1 genome location and CYP26C1 gene details page in the UCSC Genome Browser.

Further reading

• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Rat E, Billaut-Laden I, Allorge D, et al. (2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida". Birth Defects Res. A. 76 (6): 491–8. doi:10.1002/bdra.20275. PMID 16933217.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
• Wan C, Shi Y, Zhao X, et al. (2009). "Positive association between ALDH1A2 and schizophrenia in the Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 33 (8): 1491–5. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508. S2CID 32862839.
• Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.