CTDSP1

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.^[5][6][7]

CTDSP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL, 4YGY, 4YH1
Identifiers
Aliases	CTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDs	OMIM: 605323; MGI: 2654470; HomoloGene: 100834; GeneCards: CTDSP1; OMA:CTDSP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,398,256 bp[1] End 218,405,941 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C3 Start 74,430,668 bp[2] End 74,436,444 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right coronary artery gastric mucosa body of stomach Descending thoracic aorta apex of heart left uterine tube right ovary canal of the cervix popliteal artery Top expressed in granulocyte urinary bladder adrenal gland white adipose tissue muscle tissue muscle of thigh human kidney lip skeletal muscle tissue esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity metal ion binding Cellular component extracellular exosome nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II negative regulation of G1/S transition of mitotic cell cycle negative regulation of protein phosphorylation negative regulation of neurogenesis protein dephosphorylation negative regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58190 227292 Ensembl ENSG00000144579 ENSMUSG00000026176 UniProt Q9GZU7 P58466 RefSeq (mRNA) NM_001206878 NM_001206879 NM_021198 NM_182642 NM_153088 RefSeq (protein) NP_001193807 NP_067021 NP_872580 NP_694728 Location (UCSC) Chr 2: 218.4 – 218.41 Mb Chr 1: 74.43 – 74.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CTDSP1 has been shown to interact with SNAI1.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000144579 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026176 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
6. Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
7. "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
8. Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

Further reading

• Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E (September 2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134. S2CID 11308779.
• Fernandes AO, Campagnoni CW, Kampf K, Feng JM, Handley VW, Schonmann V, et al. (February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system". Journal of Neuroscience Research. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429. S2CID 29467544.
• Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN (January 2005). "Small CTD phosphatases function in silencing neuronal gene expression". Science. 307 (5709): 596–600. Bibcode:2005Sci...307..596Y. doi:10.1126/science.1100801. PMID 15681389. S2CID 39722809.
• Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.

External links

• Human CTDSP1 genome location and CTDSP1 gene details page in the UCSC Genome Browser.