CSDE1

Cold shock domain-containing protein E1 is a protein that in humans is encoded by the CSDE1 gene.^[5][6][7]

CSDE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WFQ, 1X65, 2YTV, 2YTX, 2YTY
Identifiers
Aliases	CSDE1, D1S155E, UNR, cold shock domain containing E1
External IDs	OMIM: 191510; MGI: 92356; HomoloGene: 5179; GeneCards: CSDE1; OMA:CSDE1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 114,716,913 bp[1] End 114,758,676 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 45.25 cM Start 102,927,742 bp[2] End 102,965,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon Skeletal muscle tissue of rectus abdominis glutes gastrocnemius muscle epithelium of colon Skeletal muscle tissue of biceps brachii muscle of thigh triceps brachii muscle deltoid muscle vastus lateralis muscle Top expressed in Rostral migratory stream vestibular membrane of cochlear duct lacrimal gland primitive streak abdominal wall triceps brachii muscle spermatid ankle vastus lateralis muscle knee joint More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding Cellular component CRD-mediated mRNA stability complex mitochondrial inner membrane plasma membrane Golgi apparatus cytoplasm cytosol Biological process male gonad development regulation of transcription, DNA-templated nuclear-transcribed mRNA catabolic process, no-go decay Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7812 229663 Ensembl ENSG00000009307 ENSMUSG00000068823 UniProt O75534 Q91W50 RefSeq (mRNA) NM_007158 NM_001007553 NM_001130523 NM_001242891 NM_001242892 NM_001242893 NM_001161854 NM_144901 NM_001310693 RefSeq (protein) NP_001007554 NP_001123995 NP_001229820 NP_001229821 NP_001229822 NP_009089 NP_001155326 NP_001297622 NP_659150 Location (UCSC) Chr 1: 114.72 – 114.76 Mb Chr 3: 102.93 – 102.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000009307 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068823 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jeffers M, Paciucci R, Pellicer A (Oct 1990). "Characterization of unr; a gene closely linked to N-ras". Nucleic Acids Res. 18 (16): 4891–9. PMC 331975. PMID 2204029.
6. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
7. "Entrez Gene: CSDE1 cold shock domain containing E1, RNA-binding".

External links

• Human CSDE1 genome location and CSDE1 gene details page in the UCSC Genome Browser.

Further reading

• Nicolaiew N, Triqueneaux G, Dautry F (1991). "Organization of the human N-ras locus: characterization of a gene located immediately upstream of N-ras". Oncogene. 6 (5): 721–30. PMID 2052355.
• Boussadia O, Jacquemin-Sablon H, Dautry F (1993). "Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU)". Biochim. Biophys. Acta. 1172 (1–2): 64–72. doi:10.1016/0167-4781(93)90270-N. PMID 8439573.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hunt SL, Hsuan JJ, Totty N, Jackson RJ (1999). "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA". Genes Dev. 13 (4): 437–48. doi:10.1101/gad.13.4.437. PMC 316477. PMID 10049359.
• Grosset C, Chen CY, Xu N, et al. (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell. 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545. S2CID 18135412.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mitchell SA, Spriggs KA, Coldwell MJ, et al. (2003). "The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr". Mol. Cell. 11 (3): 757–71. doi:10.1016/S1097-2765(03)00093-5. PMID 12667457.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chang TC, Yamashita A, Chen CY, et al. (2004). "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant". Genes Dev. 18 (16): 2010–23. doi:10.1101/gad.1219104. PMC 514181. PMID 15314026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Cornelis S, Tinton SA, Schepens B, et al. (2005). "UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein". Nucleic Acids Res. 33 (10): 3095–108. doi:10.1093/nar/gki611. PMC 1142345. PMID 15928332.
• Patel GP, Ma S, Bag J (2006). "The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex". Nucleic Acids Res. 33 (22): 7074–89. doi:10.1093/nar/gki1014. PMC 1316114. PMID 16356927.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.