CRYZL1

Quinone oxidoreductase-like protein 1 is an enzyme that in humans is encoded by the CRYZL1 gene.^[5][6]

CRYZL1
Identifiers
Aliases	CRYZL1, 4P11, QOH-1, crystallin zeta like 1
External IDs	OMIM: 603920; MGI: 1913859; HomoloGene: 3749; GeneCards: CRYZL1; OMA:CRYZL1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,589,341 bp[1] End 33,643,926 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 91,486,210 bp[2] End 91,525,863 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence gastric mucosa popliteal artery tibial arteries muscle layer of sigmoid colon ventricular zone Descending thoracic aorta anterior cingulate cortex left ovary amygdala Top expressed in sciatic nerve dentate gyrus of hippocampal formation granule cell Region I of hippocampus proper superior frontal gyrus medial ganglionic eminence cerebellar cortex renal corpuscle primary visual cortex Paneth cell epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity NADP binding NADPH:quinone reductase activity Cellular component cytosol Biological process quinone metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9946 66609 Ensembl ENSG00000205758 ENSMUSG00000058240 UniProt O95825 Q921W4 RefSeq (mRNA) NM_145858 NM_145311 NM_026994 NM_133679 RefSeq (protein) NP_665857 NP_081270 NP_598440 Location (UCSC) Chr 21: 33.59 – 33.64 Mb Chr 16: 91.49 – 91.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000205758 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058240 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics. 57 (1): 156–9. doi:10.1006/geno.1998.5714. PMID 10191096.
6. "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1".

External links

• Human CRYZL1 genome location and CRYZL1 gene details page in the UCSC Genome Browser.

Further reading

• Mount SM (2000). "Genomic Sequence, Splicing, and Gene Annotation". Am. J. Hum. Genet. 67 (4): 788–92. doi:10.1086/303098. PMC 1287883. PMID 10986039.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Fernández MR, Porté S, Crosas E, et al. (2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA". Cell. Mol. Life Sci. 64 (11): 1419–27. doi:10.1007/s00018-007-7091-1. PMC 11136237. PMID 17497241. S2CID 2165411.