CPA4 (gene)

Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.^[4][5][6]

CPA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BO9, 2BOA, 2PCU, 4A94, 4BD9
Identifiers
Aliases	CPA4, CPA3, carboxypeptidase A4
External IDs	OMIM: 607635; MGI: 1919041; HomoloGene: 56753; GeneCards: CPA4; OMA:CPA4 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6|6 A3.3 Start 30,568,368 bp[1] End 30,592,417 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen body of pancreas islet of Langerhans right adrenal gland left adrenal gland vagina placenta spleen minor salivary glands spinal cord Top expressed in lip esophagus skin of external ear skin of back embryo skin of abdomen ventricular zone umbilical cord morula epidermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxypeptidase activity peptidase activity zinc ion binding hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity protein binding Cellular component extracellular region extracellular space cellular component Biological process histone acetylation proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51200 71791 Ensembl n/a ENSMUSG00000039070 UniProt Q9UI42 Q6P8K8 RefSeq (mRNA) NM_016352 NM_001163446 NM_027926 RefSeq (protein) NP_001156918 NP_057436 NP_082202 Location (UCSC) n/a Chr 6: 30.57 – 30.59 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000039070 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI (Jul 1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells". Cancer Res. 59 (12): 2981–8. PMID 10383164.
5. Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
6. "Entrez Gene: CPA4 carboxypeptidase A4".

External links

• Human CPA3 genome location and CPA3 gene details page in the UCSC Genome Browser.
• Human CPA4 genome location and CPA4 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kayashima T, Yamasaki K, Yamada T, et al. (2003). "The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain". Hum. Genet. 112 (3): 220–6. doi:10.1007/s00439-002-0891-3. PMID 12552318. S2CID 45644546.
• Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome". J. Med. Genet. 40 (4): 249–56. doi:10.1136/jmg.40.4.249. PMC 1735416. PMID 12676894.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• García-Castellanos R, Bonet-Figueredo R, Pallarés I, et al. (2005). "Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin". Cell. Mol. Life Sci. 62 (17): 1996–2014. doi:10.1007/s00018-005-5174-4. PMC 11139196. PMID 16091843. S2CID 21858832.