CPA4 (gene)

Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.^[4][5][6]

CPA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BO9, 2BOA, 2PCU, 4A94, 4BD9
Identifiers
Aliases	CPA4, CPA3, carboxypeptidase A4
External IDs	OMIM: 607635; MGI: 1919041; HomoloGene: 56753; GeneCards: CPA4; OMA:CPA4 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6|6 A3.3 Start 30,568,368 bp[1] End 30,592,417 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen body of pancreas islet of Langerhans right adrenal gland left adrenal gland vagina placenta spleen minor salivary glands spinal cord Top expressed in lip esophagus skin of external ear skin of back embryo skin of abdomen ventricular zone umbilical cord morula epidermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxypeptidase activity peptidase activity zinc ion binding hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity protein binding Cellular component extracellular region extracellular space cellular component Biological process histone acetylation proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51200 71791 Ensembl n/a ENSMUSG00000039070 UniProt Q9UI42 Q6P8K8 RefSeq (mRNA) NM_016352 NM_001163446 NM_027926 RefSeq (protein) NP_001156918 NP_057436 NP_082202 Location (UCSC) n/a Chr 6: 30.57 – 30.59 Mb PubMed search [2] [3]
Wikidata
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This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.^[6]